{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T11:46:14Z","timestamp":1792669574805,"version":"4.5.0"},"reference-count":50,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2005,11,16]],"date-time":"2005-11-16T00:00:00Z","timestamp":1132099200000},"content-version":"vor","delay-in-days":10668,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1976,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cellular transfer of experimental autoimmune encephalomyelitis (EAE) was effected in mice with lymph node and spleen cells from appropriately immunized donors. In contrast to lymphoid cells, immune serum did not transfer this autoimmune disease nor did serum have any facilitating or inhibitory effect on the capacity of lymphoid cells to transfer EAE. Transfer of EAE was effected in normal mice, lightly irradiated (350 rad) and lethally irradiated (850 rad) and bone marrow\u2010protected mice, but not in mice which had been given 850 rad total\u2010body irradiation. There was a striking augmentation of severity of transferred EAE in the lightly irradiated recipients, possibly attributable to selective radiosensitivity of suppressor T cells. Cell\u2010mediated immunity but not circulating antibody to basic protein of myelin was demonstrated in recipients with transferred EAE.<\/jats:p><jats:p>The immune lymphoid cells responsible for transfer of EAE were T lymphocytes. Thus transfer was successful after passage of sensitized cells through anti\u2010immunoglobulin columns and was abrogated following treatment with anti\u2010Thy\u20101 serum and complement.<\/jats:p><jats:p>Neonatally thymectomized mice failed to develop either EAE, cell\u2010mediated immunity or humoral antibody against myelin basic protein (BPM). Inhibition of EAE and immune responsiveness was solely due to the removal of the source of thymus lymphocytes, because reconstitution of neonatally thymectomized mice with T lymphocytes completely restored these functions. It is concluded that T lymphocytes are required for the production and adoptive transfer of EAE, for the development of cell\u2010mediated immunity to BPM and for the production of antibody to BPM.<\/jats:p>","DOI":"10.1002\/eji.1830060912","type":"journal-article","created":{"date-parts":[[2007,2,28]],"date-time":"2007-02-28T04:14:09Z","timestamp":1172636049000},"page":"655-660","source":"Crossref","is-referenced-by-count":74,"title":["T cell necessity in the pathogenesis of experimental autoimmune encephalomyelitis in mice"],"prefix":"10.1002","volume":"6","author":[{"given":"C. C. A.","family":"Bernard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Leydon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. 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