{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T05:52:12Z","timestamp":1759729932267},"reference-count":19,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2005,11,16]],"date-time":"2005-11-16T00:00:00Z","timestamp":1132099200000},"content-version":"vor","delay-in-days":10607,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1976,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The level of cyclic AMP (CAMP) in human lymphocytes in the presence or absence of isoproterenol stimulation was studied in various lymphocyte subpopulations containing different proportions of B and T lymphocytes.<\/jats:p><jats:p>Lymphocytes from thymus and peripheral blood (which contain a majority of T cells) were more sensitive to isoproterenol action than lymphocytes from tonsils or adenoids (where B cells are predominant). Using purified B or T lymphocytes from peripheral blood, tonsils or adenoids, we observed an absence of B lymphocyte response to isoproterenol, whereas T lymphocytes, which had a lower basal cAMP level than B cells, exhibited in all experiments a significant increase in cAMP content after isoproterenol stimulation. The intensity of the response varied in the different T lymphocyte subpopulations.<\/jats:p>","DOI":"10.1002\/eji.1830061117","type":"journal-article","created":{"date-parts":[[2007,2,28]],"date-time":"2007-02-28T02:36:43Z","timestamp":1172630203000},"page":"834-836","source":"Crossref","is-referenced-by-count":46,"title":["Differences in effect of isoproterenol stimulation on levels of cyclic AMP in human B and T lymphocytes"],"prefix":"10.1002","volume":"6","author":[{"given":"P.","family":"Niaudet","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Genevi\u00e8ve","family":"Beaurain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie\u2010Anne","family":"Bach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,16]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(70)90024-9"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1040770112"},{"key":"e_1_2_1_4_2","first-page":"1","volume":"178","author":"Bourne H. R.","year":"1971","journal-title":"J. Pharmacol. Exp. Ther"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108254"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI106510"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.68.5.885"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107530"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107230"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.138.2.381"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.108.6.1526"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108008"},{"key":"e_1_2_1_13_2","doi-asserted-by":"crossref","first-page":"660","DOI":"10.4049\/jimmunol.114.2_Part_1.660","volume":"114","author":"Kemp R. G.","year":"1975","journal-title":"J. Immunol."},{"key":"e_1_2_1_14_2","doi-asserted-by":"crossref","first-page":"420","DOI":"10.4049\/jimmunol.112.1.420","volume":"112","author":"Greaves M. F.","year":"1974","journal-title":"J. Immunol."},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(69)90096-8"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(73)90196-7"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830031011"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.67.1.305"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-148-38468"},{"key":"e_1_2_1_20_2","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.4049\/jimmunol.115.4.1023","volume":"115","author":"Atkinson J.","year":"1975","journal-title":"J. Immunol."}],"container-title":["European Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feji.1830061117","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.1830061117","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T11:51:04Z","timestamp":1698925864000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eji.1830061117"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1976,11]]},"references-count":19,"journal-issue":{"issue":"11","published-print":{"date-parts":[[1976,11]]}},"alternative-id":["10.1002\/eji.1830061117"],"URL":"https:\/\/doi.org\/10.1002\/eji.1830061117","archive":["Portico"],"relation":{},"ISSN":["0014-2980","1521-4141"],"issn-type":[{"value":"0014-2980","type":"print"},{"value":"1521-4141","type":"electronic"}],"subject":[],"published":{"date-parts":[[1976,11]]}}}