{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T19:19:43Z","timestamp":1757704783151},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,12,7]],"date-time":"2005-12-07T00:00:00Z","timestamp":1133913600000},"content-version":"vor","delay-in-days":10082,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1978,5]]},"abstract":"Abstract<\/jats:title>Adults of two urodele amphibian species (Triturus cristatus carnifex<\/jats:italic> and Cynops hongkongensis<\/jats:italic>) and two anuran species (Rana temporaria<\/jats:italic> and Xenopus laevis laevis<\/jats:italic>) were immunized with a 25 % suspension of sheep or horse erythrocytes.<\/jats:p>After eight or 14 days, splenic lymphocytes were removed, and their specific red cell\u2010binding capacities tested by immunocytoadherence. Antigen\u2010binding cells were classified as high\u2010dose nonsecretory (S\u2212<\/jats:sup>) or secretory (S+<\/jats:sup>), according to whether they bound a single layer or several layers of erythrocytes.<\/jats:p>The stimulation of both \u03b1 and \u03b2 adrenoreceptors reduced the numbers of S+<\/jats:sup> rosettes formed by Triturus<\/jats:italic> and Cynops<\/jats:italic> lymphocytes, whereas a \u03b2 agonist increased and an \u03b1 agonist decreased S+<\/jats:sup> rosette formation by Rana<\/jats:italic> and Xenopus<\/jats:italic> splenic lymphocytes. These effects were blocked by \u03b1 and \u03b2 adrenoreceptor antagonists.<\/jats:p>Low\u2010dose immunization of Xenopus<\/jats:italic> with a 0.0025% suspension of sheep erythrocytes gave a minimal number of S+<\/jats:sup> rosettes two and eight days after immunization, and \u03b2 adrenoreceptor stimulation had no effect on antigen binding.<\/jats:p>These results are discussed in terms of the distribution of \u03b1 and \u03b2 adrenoreceptors in amphibians and possible relationships between S+<\/jats:sup> and high\u2010dose S\u2212<\/jats:sup> antigen\u2010binding cells, and support the view that functional lymphocyte heterogeneity exists in these lower vertebrates.<\/jats:p>","DOI":"10.1002\/eji.1830080511","type":"journal-article","created":{"date-parts":[[2007,2,28]],"date-time":"2007-02-28T09:50:32Z","timestamp":1172656232000},"page":"348-351","source":"Crossref","is-referenced-by-count":11,"title":["The effects of \u03b1 and \u03b2 adrenergic agents on spleen cell antigen binding in four amphibian species"],"prefix":"10.1002","volume":"8","author":[{"given":"Ruth M.","family":"Hodgson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. 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