{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T19:18:49Z","timestamp":1699643929878},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,11,16]],"date-time":"2005-11-16T00:00:00Z","timestamp":1132099200000},"content-version":"vor","delay-in-days":9816,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1979,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Plaque\u2010forming cell (PFC) responses to 2,4,6\u2010trinitrophenylated lipopolysaccharide (TNP\u2010LPS) were studied in normal and immunodeficient mice. <jats:italic>In vivo<\/jats:italic> immunizations with TNP\u2010LPS showed a 25\u201350% reduction in PFC responses in CBA\/N mice and their (CBA\/N \u00d7 BALB\/c)F<jats:sub>1<\/jats:sub>(NBF<jats:sub>1<\/jats:sub>) male hybrids with an X\u2010linked immune defect of B lymphocyte differentiation. A detailed clonal analysis of the reduced responses to TNP\u2010LPS revealed that CBA\/N and NBF<jats:sub>1<\/jats:sub> male mice with the X\u2010linked genetic defect have fewer precursor B cells engaged in the response to TNP\u2010LPS than the control mice. The reduction in precursor cell numbers affects selectively B cells secreting high avidity anti\u2010TNP antibodies as determined by PFC inhibition studies.<\/jats:p>","DOI":"10.1002\/eji.1830090114","type":"journal-article","created":{"date-parts":[[2007,2,28]],"date-time":"2007-02-28T10:11:04Z","timestamp":1172657464000},"page":"67-71","source":"Crossref","is-referenced-by-count":13,"title":["The immune response of CBA\/N mice and their F<sub>1<\/sub> hybrids to 2,4,6\u2010trinitrophenylated (TNP) antigens I. 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