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This suppression of DTH was transferable by spleen, lymph node, thymus and bone marrow cells to sensitize or normal syngeneic recipients, but could not be transferred by serum. Suppressor cells were not induced by LPS alone or SRBC alone, and they were antigen\u2010specific since DTH to chicken red blood cells was not affected. The suppressor cells appeared in the spleen in optimum number 3\u20134 days after induction. They were theta\u2010negative and Ig\u2010positive as judged by antiserum plus complement treatment and by Ig rosette separation. Attempts to obtain soluble suppressor factor from the suppressor cells by sanitation or <jats:italic>in vitro<\/jats:italic> incubation were unsuccessful. Mitomycin C treatment of the suppressor cells completely abolished the suppressor activity. Thus, LPS, in conjunction with antigen, appears to induce a population of specific suppressor B cells which are capable of regulating T cell function.<\/jats:p>","DOI":"10.1002\/eji.1830090202","type":"journal-article","created":{"date-parts":[[2007,2,28]],"date-time":"2007-02-28T10:41:15Z","timestamp":1172659275000},"page":"101-106","source":"Crossref","is-referenced-by-count":14,"title":["Regulation of delayed\u2010type hypersensitivity. IV. 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