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These cultures were stimulated with syngeneic cells conjugated with different concentrations of trinitrobenzene sulfonate (TNP\u2010self) or FITC (FITC\u2010self). The results demonstrate (a) appreciable helper cell activity from TNP\u2010self and FITC\u2010self\u2010primed mice, as determined by enhanced hapten\u2010specific cytotoxic T lymphocyte (CTL) responses, (b) that FITC helper activity enhanced the FITC\u2010self CTL more efficiently than the TNP\u2010self CTL response, and <jats:italic>vice versa<\/jats:italic>, (c) an alloantigenic stimulating population failed to activate TNP\u2010self helper activity and (d) that the helper activity was not exclusively specific, since FITC helpers did enhance the anti TNP CTL response, and TNP helpers could enhance the anti\u2010FITC\u2010self CTL response. The results of this study indicate that these cell\u2010mediated lympholysis models permit an analysis of hapten specificity and cross\u2010reactivity at the different levels of cellular interaction involved in the generation of an H\u20102\u2010restricted CTL response.<\/jats:p>","DOI":"10.1002\/eji.1830101203","type":"journal-article","created":{"date-parts":[[2007,2,28]],"date-time":"2007-02-28T12:20:17Z","timestamp":1172665217000},"page":"904-907","source":"Crossref","is-referenced-by-count":3,"title":["Helper cell analysis in cytotoxic T lymphocyte responses I. Activation of specific and cross\u2010reactive helper effects in two hapten\u2010modified self responses"],"prefix":"10.1002","volume":"10","author":[{"given":"Robert B.","family":"Levy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromi","family":"Fujiwara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gene M.","family":"Shearer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,16]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.141.6.1348"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.142.2.403"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830061109"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830090905"},{"key":"e_1_2_1_6_2","unstructured":"Gilheany P. 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