{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:02:47Z","timestamp":1762160567504},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2005,11,16]],"date-time":"2005-11-16T00:00:00Z","timestamp":1132099200000},"content-version":"vor","delay-in-days":9085,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1981,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Evidence is presented for the involvement of immediate hypersensitivity phenomena in experimental autoimmune uveoretinitis, an ocular inflammatory disease induced in Lewis rats by injection of the purified S antigen from bovine retina. Several parameters at various dates after immunization have been studied. <jats:italic>In vivo<\/jats:italic> degranulation of choroidal mast cells, <jats:italic>in vitro<\/jats:italic> degranulation of peritoneal mast cells in the presence of S antigen and cutaneous anaphylaxis were observed as early as 6\u20138 days after immunization. Serum antibodies were detected by passive hemagglutination from day 7 on. These phenomena preceded the onset of the ocular inflammation, consisting of a transient polymorphonuclear leukocyte infiltration, a long\u2010lasting lymphoid cell infiltration and extensive damage to the retina and surrounding tissues. Such time course of events may suggest a role for reaginic antibody as a trigger for vascular changes in the target ocular tissue, favoring the development of inflammatory lesions.<\/jats:p>","DOI":"10.1002\/eji.1830110805","type":"journal-article","created":{"date-parts":[[2007,2,28]],"date-time":"2007-02-28T14:10:16Z","timestamp":1172671816000},"page":"612-617","source":"Crossref","is-referenced-by-count":66,"title":["Evidence for immediate hypersensitivity phenomena in experimental autoimmune uveoretinitis"],"prefix":"10.1002","volume":"11","author":[{"given":"Yvonne","family":"de Kozak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean","family":"Sainte\u2010Laudy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques","family":"Benveniste","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Pierre","family":"Faure","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,16]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"215","volume":"2","author":"Faure J. 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