{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T09:53:01Z","timestamp":1774950781412,"version":"3.50.1"},"reference-count":52,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2005,11,16]],"date-time":"2005-11-16T00:00:00Z","timestamp":1132099200000},"content-version":"vor","delay-in-days":9085,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1981,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The experiments show that the phenomenon of regression, seen exclusively in Epstein\u2010Barr (EB) virus\u2010infected cultures of mononuclear cells from EB virus antibody\u2010positive donors, is mediated by cytotoxic T cells reactivated <jats:italic>in vitro<\/jats:italic> and specifically recognizing an EB virus\u2010induced lymphocyte\u2010detected membrane antigen LYDMA. Thus, effector T cells from regressing cultures kill autologous EB virus\u2010transformed cells but not autologous pokeweed mitogen\u2010stimulated lymphoblasts nor any of a range of EB virus genome\u2010negative human hemopoietic cell lines (K562, HSB2, BJAB, EB4) particularly sensitive to nonspecific natural killer\u2010like activities. Moreover, these reactivated effector cells exhibit classical HLA restriction of target cell recognition; in a survey of 14 effector cell donors, preferential lysis of the autologous virus\u2010transformed line was a consistent feature, while the relative degree of lysis of allogeneic lines was in general directly related to the number of HLA\u2010A and B antigens shared between effector and target cells. The pattern of reactivity shown by effector T cell preparations from any one donor was strikingly reproducible, and the results from a number of donors revealed differences between particular HLA\u2010A and B antigens with respect to the level of EB virus\u2010specific killing which was associated with sharing through these determinants.<\/jats:p>","DOI":"10.1002\/eji.1830110904","type":"journal-article","created":{"date-parts":[[2007,2,28]],"date-time":"2007-02-28T14:10:06Z","timestamp":1172671806000},"page":"686-693","source":"Crossref","is-referenced-by-count":70,"title":["Cytotoxic T cell recognition of Epstein\u2010Barr virus\u2010infected B cells. I. Specificity and HLA restriction of effector cells reactivated <i>in vitro<\/i>"],"prefix":"10.1002","volume":"11","author":[{"given":"Denis J.","family":"Moss","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lesley E.","family":"Wallace","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan B.","family":"Rickinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Anthony","family":"Epstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,16]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910080312"},{"key":"e_1_2_1_3_2","first-page":"724","volume":"36","author":"Klein E.","year":"1976","journal-title":"Cancer Res."},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.mi.31.100177.002225"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(73)91148-3"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.72.4.1622"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197512042932301"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(78)94347-1"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/251547a0"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.141.2.502"},{"key":"e_1_2_1_11_2","first-page":"89","volume":"29","author":"Doherty P. C.","year":"1976","journal-title":"Trans plant. Rev."},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/269806a0"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(79)80071-3"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.150.6.1310"},{"key":"e_1_2_1_15_2","unstructured":"Seeley J. Svedmyr E. Weiland O. Klein G. M\u00f6ller E. Eriksson E. Andersson K.andvan der Waal L. J. Immunol. in press."},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910220604"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910230505"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910230506"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/283865a0"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.7.4247"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830110905"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-38-3-449"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(74)90003-9"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.1977.tb02229.x"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1978.tb00517.x"},{"key":"e_1_2_1_26_2","first-page":"2012","volume":"30","author":"Krishan A.","year":"1970","journal-title":"Cancer Res."},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V45.3.321.321"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.71.8.3283"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1966.58"},{"key":"e_1_2_1_30_2","first-page":"493","volume":"27","author":"Reed L. J.","year":"1938","journal-title":"Am. J. Hyg."},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910250108"},{"key":"e_1_2_1_32_2","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.4049\/jimmunol.119.4.1351","volume":"119","author":"Ortaldo J. R.","year":"1977","journal-title":"J. Immunol."},{"key":"e_1_2_1_33_2","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.4049\/jimmunol.122.4.1489","volume":"122","author":"Ortaldo J. R.","year":"1979","journal-title":"J. Immunol."},{"key":"e_1_2_1_34_2","first-page":"1325","volume":"36","author":"Ortaldo J. R.","year":"1977","journal-title":"Fed. Proc."},{"key":"e_1_2_1_35_2","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.4049\/jimmunol.120.4.1415","volume":"120","author":"Seeley J. K.","year":"1978","journal-title":"J. Immunol."},{"key":"e_1_2_1_36_2","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.4049\/jimmunol.123.3.1303","volume":"123","author":"Seeley J. K.","year":"1979","journal-title":"J. Immunol."},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910130617"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1974.tb01283.x"},{"key":"e_1_2_1_39_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1975.tb02680.x"},{"key":"e_1_2_1_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(78)90032-1"},{"key":"e_1_2_1_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-8749(78)80023-9"},{"key":"e_1_2_1_42_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.147.6.1621"},{"key":"e_1_2_1_43_2","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.4049\/jimmunol.124.3.1045","volume":"124","author":"Sugamura K.","year":"1980","journal-title":"J. Immunol."},{"key":"e_1_2_1_44_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.128.5.1011"},{"key":"e_1_2_1_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/266544a0"},{"key":"e_1_2_1_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/270524a0"},{"key":"e_1_2_1_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/270526a0"},{"key":"e_1_2_1_48_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830070816"},{"key":"e_1_2_1_49_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.bmb.a071518"},{"key":"e_1_2_1_50_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830090804"},{"key":"e_1_2_1_51_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.149.2.545"},{"key":"e_1_2_1_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(08)60262-X"},{"key":"e_1_2_1_53_2","unstructured":"Rickinson A. B. Moss D. J. Wallace L. E. Rowe M. Misko I. S. Epstein M. A.andPope J. H. Cancer Res. in press."}],"container-title":["European Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feji.1830110904","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.1830110904","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T09:05:21Z","timestamp":1698915921000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eji.1830110904"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,1]]},"references-count":52,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1981,1]]}},"alternative-id":["10.1002\/eji.1830110904"],"URL":"https:\/\/doi.org\/10.1002\/eji.1830110904","archive":["Portico"],"relation":{},"ISSN":["0014-2980","1521-4141"],"issn-type":[{"value":"0014-2980","type":"print"},{"value":"1521-4141","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,1]]}}}