{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T13:11:16Z","timestamp":1790169076726,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2005,11,16]],"date-time":"2005-11-16T00:00:00Z","timestamp":1132099200000},"content-version":"vor","delay-in-days":9085,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1981,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Helminth infections in mammals are characterized by a high level of eosinophils in parasitized tissues and blood, and it has recently been suggested that these cells have a direct parasiticidal effect. Newborn larvae of <jats:italic>Trichinella spiralis<\/jats:italic> can be killed within 20 min by incubation at room temperature in a cell\u2010free system, including purified human eosinophil peroxidase (EPO), H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> and chloride at pH 5.5. Killing was measured by microscopic observation of the larvae. The larvicidal effect was dependent on each component of the EPO\/H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>\/Cl<jats:sup>\u2212<\/jats:sup> system and could be prevented by using SO<jats:sub>4<\/jats:sub><jats:sup>2\u2212<\/jats:sup> instead of Cl<jats:sup>\u2212.<\/jats:sup> Killing was totally inhibited by sodium azide and catalase, and substantially by bovine serum albumin, a protein that is an effective scavenger for HOCI. Since larvae could also be killed directly by HOCI under these conditions and EPO is able to oxidize Cl<jats:sup>\u2212<\/jats:sup> to hypochlorous acid, it is very likely that the larvicidal effect of the EPO system is due to formation of hypochlorous acid. It is proposed that <jats:italic>in vivo<\/jats:italic>, the combination of EPO, which is exocytosed onto the surface of the parasite, and H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>, which is generated by stimulated eosinophils, is responsible for the larvicidal effect.<\/jats:p>","DOI":"10.1002\/eji.1830111018","type":"journal-article","created":{"date-parts":[[2007,2,28]],"date-time":"2007-02-28T13:25:35Z","timestamp":1172669135000},"page":"843-845","source":"Crossref","is-referenced-by-count":49,"title":["The killing of newborn larvae of <i>Trichinella spiralis<\/i> by eosinophil peroxidase <i>in vitro<\/i>"],"prefix":"10.1002","volume":"11","author":[{"given":"Jannie","family":"Buys","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron","family":"Wever","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rien","family":"van Stigt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. 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