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The vesicles were allowed to fuse with the membranes of normal human B lymphocytes, whereafter the cells were infected with transforming EBV (B95\u20108 substrain). Compared to similarly infected but otherwise unmanipulated cells, the receptor\u2010implanted lymphocytes responded with a larger number of EBV\u2010determined nuclear antigen positive and immunoglobulin\u2010secreting plaque\u2010forming cells (PFC). Moreover, there was a clear increase of the IgG\/IgM PFC ratio in the receptor\u2010implanted B lymphocytes. These results show that not all human B lymphocytes that can potentially be activated by EBV express functional EBV receptors. 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