{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T23:52:32Z","timestamp":1770508352918,"version":"3.49.0"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2005,12,11]],"date-time":"2005-12-11T00:00:00Z","timestamp":1134259200000},"content-version":"vor","delay-in-days":8745,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1982,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mercuric chloride induces an immune glomerulonephritis in Brown\u2010Norway (BN) but not in Lewis (LEW) rats. Injection of HgCl<jats:sub>2<\/jats:sub> into BN rats regularly produced a transient appearance of plaque\u2010forming cells (PFC) of anti\u20102,4,6\u2010trinitrophenyl and anti\u2010sheep red blood cell specificity and circulating anti\u2010single\u2010stranded DNA antibodies. Addition of HgCl<jats:sub>2<\/jats:sub> to spleen cell cultures from BN rats induced an increase in anti\u2010trinitrophenyl PFC and reverse PFC. This effect was no longer observed when nylon wool column\u2010depleted or anti\u2010Thy\u20101 antiserum\u2010treated spleen cells were cultured in the presence of HgCl<jats:sub>2<\/jats:sub>. These data suggest that HgCl<jats:sub>2<\/jats:sub> acts as a polyclonal activator on spleen cells in BN rats, but not on isolated B lymphocytes. In contrast, no effect of HgCl<jats:sub>2<\/jats:sub> on immunoglobulin production was observed in LEW rats. Since polyclonal activation and immune\u2010type nephritis are both seen in BN but not in LEW rats, polyclonal activation may participate in the pathogenesis of the HgCl<jats:sub>2<\/jats:sub>\u2010induced autoimmune disease of BN rats.<\/jats:p>","DOI":"10.1002\/eji.1830120716","type":"journal-article","created":{"date-parts":[[2007,2,28]],"date-time":"2007-02-28T18:51:37Z","timestamp":1172688697000},"page":"620-625","source":"Crossref","is-referenced-by-count":133,"title":["Polyclonal effect of HgCl<sub>2<\/sub> in the rat, its possible role in an experimental autoimmune disease"],"prefix":"10.1002","volume":"12","author":[{"given":"Francois","family":"Hirsch","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques","family":"Couderc","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Sapin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilbert","family":"Fournie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Druet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,11]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"173","volume":"28","author":"Sapin C.","year":"1977","journal-title":"Clin. Exp. Immunol."},{"key":"e_1_2_1_3_2","first-page":"777","volume":"129","author":"Druet P.","year":"1978","journal-title":"Ann. Immunol. (Paris)"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830070605"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"296","DOI":"10.4049\/jimmunol.122.1.296","volume":"122","author":"Kobayakawa T.","year":"1979","journal-title":"J Immunol."},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01891670"},{"key":"e_1_2_1_7_2","first-page":"392","volume-title":"Prog. Allergy","author":"Simonsen M.","year":"1962"},{"key":"e_1_2_1_8_2","first-page":"293","volume":"65","author":"Bariety J.","year":"1971","journal-title":"Am. J. Pathol."},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830100807"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.132.3441.1770"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(71)90070-0"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj1870001"},{"key":"e_1_2_1_13_2","first-page":"52","volume":"6","author":"Raff M.","year":"1971","journal-title":"Transplant. Rev."},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.126.3.423"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830031011"},{"key":"e_1_2_1_16_2","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.4049\/jimmunol.113.4.1093","volume":"113","author":"Trizio D.","year":"1974","journal-title":"J Immunol."},{"key":"e_1_2_1_17_2","first-page":"425","volume":"26","author":"Izui S.","year":"1976","journal-title":"Clin. Exp. Immunol."},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00787a005"},{"key":"e_1_2_1_19_2","first-page":"599","volume":"14","author":"Cunningham A. J.","year":"1968","journal-title":"Immunology"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-132-34264"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830060812"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830100510"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.1982.tb00949.x"},{"key":"e_1_2_1_24_2","doi-asserted-by":"crossref","first-page":"699","DOI":"10.4049\/jimmunol.126.2.699","volume":"126","author":"Prouvost\u2010Danon A.","year":"1981","journal-title":"J. Immunol."},{"key":"e_1_2_1_25_2","first-page":"245","volume-title":"Actualit\u00e9s N\u00e9phrologiques de \u013eH\u00f4pital Necker","author":"Druet P.","year":"1978"},{"key":"e_1_2_1_26_2","first-page":"405","volume":"39","author":"Weening J. J.","year":"1978","journal-title":"Lab. Invest."},{"key":"e_1_2_1_27_2","first-page":"64","volume":"45","author":"Weening J. J.","year":"1981","journal-title":"Clin. Exp. Immunol."},{"key":"e_1_2_1_28_2","first-page":"153","volume":"2","author":"Charpentier B.","year":"1982","journal-title":"N\u00e9phrologie"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1979.tb00273.x"},{"key":"e_1_2_1_30_2","first-page":"959","volume-title":"Immunology 80","author":"Dixon F. J.","year":"1980"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198004103021502"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(79)92174-3"}],"container-title":["European Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feji.1830120716","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.1830120716","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T06:47:04Z","timestamp":1698907624000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eji.1830120716"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,1]]},"references-count":31,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1982,1]]}},"alternative-id":["10.1002\/eji.1830120716"],"URL":"https:\/\/doi.org\/10.1002\/eji.1830120716","archive":["Portico"],"relation":{},"ISSN":["0014-2980","1521-4141"],"issn-type":[{"value":"0014-2980","type":"print"},{"value":"1521-4141","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982,1]]}}}