{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T00:56:01Z","timestamp":1698972961745},"reference-count":31,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":8743,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1982,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Previous studies have shown that anti\u2010IgD\u2010suppressed mice give normal primary and secondary splenic plaque\u2010forming cell responses following i.v. challenge, although mice suppressed by the injection of anti\u2010IgD from birth lack IgD\u2010bearing cells in all lymphoid tissue examined. The present studies show that, in contrast, secondary immune responses in regional lymph nodes of such mice, even after i.v. priming with trinitrophenylated <jats:italic>B. abortus<\/jats:italic>, respond to a challenge injection in the footpad up to only &lt; 10% of control levels. When compared with respect to B cell numbers transferred, primed spleen cells from control and anti\u2010IgD\u2010suppressed mice are about equally effective in producing adoptive secondary plaque\u2010forming cell responses in the spleens of recipient mice. Lymph nodes in recipients of anti\u2010IgD\u2010suppressed primed spleen cells show much lower responses than do lymph nodes in recipients of control primed cells, both upon immediate and delayed challenge with antigen in the footpads. It is concluded that the immunodeficiency caused by suppression with anti\u2010IgD is much more marked in peripheral lymph nodes than in the spleen. The possible relationship of these results to the migratory properties of IgD<jats:sup>+<\/jats:sup> as compared to IgD<jats:sup>\u2212<\/jats:sup> B cells is discussed.<\/jats:p>","DOI":"10.1002\/eji.1830121015","type":"journal-article","created":{"date-parts":[[2007,2,28]],"date-time":"2007-02-28T14:37:05Z","timestamp":1172673425000},"page":"882-886","source":"Crossref","is-referenced-by-count":3,"title":["Physiology of IgD. II. Lack of humoral immune responsiveness in lymph nodes of mice treated with anti\u2010IgD from birth"],"prefix":"10.1002","volume":"12","author":[{"given":"Yaela","family":"Baine","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yung\u2010Wu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ethel B.","family":"Jacobson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben","family":"Pernis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory W.","family":"Siskind","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. Jeanette","family":"Thorbecke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,9]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.154.2.318"},{"key":"e_1_2_1_3_2","first-page":"201","volume-title":"B Lymphocytes in the Immune Response: Functional, Developmental, and Interactive Properties","author":"Metcalf E. S.","year":"1981"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(77)90231-3"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830111208"},{"key":"e_1_2_1_6_2","first-page":"128","volume-title":"Methods in Immunology and Immunochemistry","author":"Little J. R.","year":"1968"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(75)90011-8"},{"key":"e_1_2_1_8_2","first-page":"120","volume-title":"Methods in Immunology and Immunochemistry","author":"Nisonoff A.","year":"1968"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"671","DOI":"10.4049\/jimmunol.115.3.671","volume":"115","author":"Kearney J. F.","year":"1975","journal-title":"J. Immunol."},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/27.8.90074"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.126.3.423"},{"key":"e_1_2_1_12_2","first-page":"109","volume-title":"Cell\u2010Bound Antibody","author":"Jerne N. K.","year":"1963"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-132-34264"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(78)90145-4"},{"key":"e_1_2_1_15_2","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.4049\/jimmunol.120.6.2041","volume":"120","author":"Abney E. R.","year":"1978","journal-title":"J. Immunol."},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.144.3.852"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.141.1.206"},{"key":"e_1_2_1_18_2","unstructured":"Skelly R. Baine Y. Ahmed A. Xue B.andThorbecke G. J. J. Immunol in press."},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.146.1.297"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830111103"},{"key":"e_1_2_1_21_2","volume-title":"In Vivo Immunology: Histophysiology of the Lymphoid System","author":"Thorbecke G. J."},{"key":"e_1_2_1_22_2","first-page":"367","volume":"31","author":"Brandtzaeg P.","year":"1978","journal-title":"Clin. Exp. Immunol."},{"key":"e_1_2_1_23_2","first-page":"865","volume":"38","author":"Martin L. N.","year":"1977","journal-title":"Immunology"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.135.2.200"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(73)90180-9"},{"key":"e_1_2_1_26_2","first-page":"84","volume":"24","author":"Strober S.","year":"1975","journal-title":"Transplant. Rev."},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830111104"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830110206"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830080507"},{"key":"e_1_2_1_30_2","unstructured":"Ovary Z. Baine Y. Hirano T. Xue B. Pernis B.andThorbecke G. J. Ann. N. Y. Acad. Sci. in press."},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.151.5.1071"},{"key":"e_1_2_1_32_2","doi-asserted-by":"crossref","first-page":"420","DOI":"10.4049\/jimmunol.125.1.420","volume":"125","author":"Pure E.","year":"1980","journal-title":"J. Immunol."}],"container-title":["European Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feji.1830121015","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.1830121015","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T17:09:39Z","timestamp":1698944979000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eji.1830121015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,1]]},"references-count":31,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1982,1]]}},"alternative-id":["10.1002\/eji.1830121015"],"URL":"https:\/\/doi.org\/10.1002\/eji.1830121015","archive":["Portico"],"relation":{},"ISSN":["0014-2980","1521-4141"],"issn-type":[{"value":"0014-2980","type":"print"},{"value":"1521-4141","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982,1]]}}}