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In parallel the cells were stained with fluorescent anti\u2010Thy\u20101 and various anti\u2010Ig antisera, and were analyzed on a fluorescence\u2010activated cell sorter (FACS). By comparison with normal spleen cells the cells of TLI\u2010treated mice gave a high response to dextran sulfate and a low response to lipopolysaccharide. FACS analysis revealed that TLI\u2010treated spleen contains elevated numbers of B cells bearing high IgM and low IgD on the surface. The B cells of TLI\u2010treated mice retained these immature characteristics even two to four months after the last irradiation. These findings indicate that TLI causes a longlasting blockage in B cell maturation processes.<\/jats:p>","DOI":"10.1002\/eji.1830130109","type":"journal-article","created":{"date-parts":[[2007,2,28]],"date-time":"2007-02-28T19:51:18Z","timestamp":1172692278000},"page":"35-40","source":"Crossref","is-referenced-by-count":12,"title":["Modulation of B and T cell subsets in mice treated with fractionated total lymphoid irradiation. I. Blockage of differentiating B cell pathways"],"prefix":"10.1002","volume":"13","author":[{"given":"Israel","family":"Zan\u2010Bar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,11,16]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"283","volume-title":"Hodgkin Disease","author":"Kaplan H. 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