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If donor mice were given SRBC orally for 4\u20135 weeks prior to transfer, the adoptively transferred PP IgG and IgA responses were considerably suppressed, although the IgM responses were often unaffected. Co\u2010injection of PP cells from antigen\u2010fed mice with PP cells from normal mice resulted in marked suppression of the normal PP IgG and IgA response. However, treatment of PP cells from antigen\u2010fed mice with anti\u2010Thy\u20101.2 plus complement prior to cotransfer completely abrogated suppression of the IgG PFC response and partially abrogated the suppressed IgA response. B cells from the PP of antigen\u2010fed mice, when transferred into SRBC\u2010primed irradiated recipients (to provide T cell help) generated 2\u20133 times more IgG and IgA PFC than comparable numbers of B cells from the PP of normal mice. Thus antigen feeding generates suppressor T cells in PP which can mask the expression of B cell priming to orally administered antigen.<\/jats:p>","DOI":"10.1002\/eji.1830130209","type":"journal-article","created":{"date-parts":[[2007,2,28]],"date-time":"2007-02-28T20:01:12Z","timestamp":1172692872000},"page":"138-142","source":"Crossref","is-referenced-by-count":44,"title":["Immunosuppression caused by antigen feeding II. Suppressor T cells mask Peyer's patch B cell priming to orally administered antigen"],"prefix":"10.1002","volume":"13","author":[{"given":"Thomas Thornton","family":"Macdonald","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,16]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.149.1.216"},{"key":"e_1_2_1_3_2","first-page":"61s","volume":"28","author":"Cebra J. J.","year":"1980","journal-title":"J. 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