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High IFN titers were also observed after stimulation of <jats:italic>L. monocytogenes<\/jats:italic>\u2010immune cell cultures with the T cell mitogens concanavalin A and phytohemagglutinin. <jats:italic>L. monocytogenes<\/jats:italic>\u2010immune PETLEC produced several fold higher IFN titers than normal cell cultures in response to mitogen and antigen. Under both circumstances, APC were required for optimum responses. <jats:italic>L. monocytogenes<\/jats:italic>\u2010immune PETLEC participating in IFN production were Lyt 1<jats:sup>+<\/jats:sup>23<jats:sup>\u2212<\/jats:sup>. IFN\u2010\u03b3 was also produced in cultures of cloned <jats:italic>L. monocytogenes<\/jats:italic>\u2010specific T cells. Since the same T cell clone showed antigen\u2010specific proliferative responses and interleukin production <jats:italic>in vitro<\/jats:italic>, and could adoptively mediate delayed\u2010type hypersensitivity and anti\u2010listerial protection <jats:italic>in vivo<\/jats:italic>, it is suggested that IFN production is a function of specific T cells active in cellular antibacterial immunity.<\/jats:p>","DOI":"10.1002\/eji.1830130318","type":"journal-article","created":{"date-parts":[[2007,2,28]],"date-time":"2007-02-28T20:00:45Z","timestamp":1172692845000},"page":"265-268","source":"Crossref","is-referenced-by-count":57,"title":["Interferon\u2010\u03b3 production by <i>Listeria monocytogenes<\/i>\u2010specific T cells active in cellular antibacterial immunity"],"prefix":"10.1002","volume":"13","author":[{"given":"Stefan H. 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