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By single\u2010 and two\u2010color flow cytofluorometry analysis this mAb was found to stain brightly 80\u201390% of T cells in enlarged MRL\u2010lpr lymph nodes. In contrast lymph node T cells from congenic MRL\u2010MP\u2010+\/+ (MRL\u2010+) mice were either unstained (70%) or weakly stained (30%), these latter cells being mostly Lyt\u20102<jats:sup>+<\/jats:sup>. Unexpectedly, all lymph node B cells from MRL\u2010+ or MRL\u2010lpr mice were as strongly 100C5<jats:sup>+<\/jats:sup> as MRL\u2010lpr T cells. Similar observations were made in C57BL\/6\u2010<jats:italic>lpr\/lpr<\/jats:italic> and C57BL\/6\u2010+\/+ mice. Molecular weight determination suggested that the 100C5 mAb binds to the same molecule (M<jats:sub>r<\/jats:sub> = 220000) on MRL\u2010lpr T cells and normal B cells.<\/jats:p>","DOI":"10.1002\/eji.1830130605","type":"journal-article","created":{"date-parts":[[2007,2,28]],"date-time":"2007-02-28T20:22:51Z","timestamp":1172694171000},"page":"455-459","source":"Crossref","is-referenced-by-count":21,"title":["A monoclonal antibody (100C5) to the Lyt\u20102<sup>\u2212<\/sup> T cell population expanding in MRL\/Mp\u2010<i>lpr\/lpr<\/i> mice detects a surface antigen normally expressed on Lyt\u20102<sup>+<\/sup> cells and B cells"],"prefix":"10.1002","volume":"13","author":[{"given":"Francis J.","family":"Dumont","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert C.","family":"Habbersett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth A.","family":"Nichols","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline A.","family":"Treffinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amar S.","family":"Tung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,16]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"1246","volume":"36","author":"Murphy E. 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