{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T01:55:13Z","timestamp":1698026113436},"reference-count":27,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2005,11,16]],"date-time":"2005-11-16T00:00:00Z","timestamp":1132099200000},"content-version":"vor","delay-in-days":8355,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1983,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The present findings demonstrate that a total i. v. transfer of 100 \u00d7 10<jats:sup>6<\/jats:sup> C57BL\/6 (B6) parental spleen cells into untreated (C57BL\/6 \u00d7 DBA\/2)F<jats:sub>1<\/jats:sub> hybrids (B6D2F<jats:sub>1<\/jats:sub>) resulted in acute runting, which was associated with a significantly elevated graft\u2010<jats:italic>vs.<\/jats:italic>\u2010host (GVH) index over a one\u2010month period following GVH induction. Furthermore, this B6\u2010induced acute GVH disease was associated with a marked depression of natural killer (NK) cell activity (spleen and peripheral blood) (with or without addition of mouse fibroblast interferon), which correlated with lymphoid cell hypocellularity, prominent splenic extramedullary hematopoiesis (EMH), and parallel depressions of both concanavalin A\u2010 and lipopolysaccharide\u2010induced mitogenesis. Significantly increased killing by antibody\u2010dependent cellular cytotoxicity of antibody\u2010coated chicken red blood cells, as well as increased T cell killing of the NK\u2010insensitive cell line P815 (as compared to the significantly decreased killing of the NK\u2010sensitive cell line YAC\u20101) was also observed in the spleens of this 100 \u00d7 10<jats:sup>6<\/jats:sup> B6\u2010injected F<jats:sub>1<\/jats:sub> group.<\/jats:p><jats:p>In marked contrast to this 100 \u00d7 10<jats:sup>6<\/jats:sup> B6\u2010injected acute GVH group, untreated mice injected i. v. with the same or greater numbers of parental DBA\/2 spleen cells (100 \u00d7 10<jats:sup>6<\/jats:sup>\u2010150 \u00d7 10<jats:sup>6<\/jats:sup> DBA\/2 spleen cells) exhibited a milder and more chronic form of GVH disease, which was not associated with a significant decrease of NK activity. It was of considerable interest that a total i. v. transfer of 50 \u00d7 10<jats:sup>6<\/jats:sup> B6 spleen cells (<jats:italic>i.e.<\/jats:italic> one\u2010half of that required to produce acute GVH, markedly depressed NK, and prominent splenic EMH) into B6D2F<jats:sub>1<\/jats:sub> hybrids also resulted in a more chronic form of GVH disease, but was associated with significantly increased levels of NK activity at two weeks post GVH induction.<\/jats:p>","DOI":"10.1002\/eji.1830131110","type":"journal-article","created":{"date-parts":[[2007,2,28]],"date-time":"2007-02-28T19:26:23Z","timestamp":1172690783000},"page":"912-919","source":"Crossref","is-referenced-by-count":15,"title":["Natural killer activity in (C57BL\/6 \u00d7 DBA\/2)F<sub>1<\/sub> hybrids undergoing acute and chronic graft\u2010<i>vs.<\/i>\u2010host reaction"],"prefix":"10.1002","volume":"13","author":[{"given":"Paul K.","family":"Pattengale","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Urban","family":"Ramstedt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magnus","family":"Gidlund","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"\u00d6rn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inger","family":"Axberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans","family":"Wigzell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,16]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4684-9066-4_75"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(77)90227-1"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1978.tb00446.x"},{"key":"e_1_2_1_5_2","first-page":"339","volume":"17","author":"Lapp W. 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