{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T01:00:42Z","timestamp":1697936442161},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,11,16]],"date-time":"2005-11-16T00:00:00Z","timestamp":1132099200000},"content-version":"vor","delay-in-days":7990,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1984,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Allogeneic irradiation bone marrow chimeras C57BL\/10 (H\u20102<jats:sup>b<\/jats:sup>) \u2192B10.BR (H\u20102<jats:sup>k<\/jats:sup>) and B10.BR (H\u20102<jats:sup>k<\/jats:sup>)\u2192C57BL\/10 (H\u20102<jats:sup>b<\/jats:sup>) were raised under specific pathogen\u2010free (SPF) conditions; they survived very well and were healthy under SPF for 3\u20134 months and subsequently, under conventional housing conditions, for 1 to 8 months. Their immune response against third\u2010party alloantigens was comparable with that of controls. Anti\u2010vaccinia virus responses were very low when compared with syngeneic control chimeras or unmanipulated control animals; if anti\u2010vaccinia virus cytotoxic T cell reactivity was measurable, it was specific for the bone marrow donor, rather than the recipient thymic H\u20102 type. In contrast, the anti\u2010LCMV (lymphocytic\u2010choriomeningitis virus) response was excellent and comparable to that in controls for B10.BR (H\u20102<jats:sup>k<\/jats:sup>)\u2192C57BL\/10 (H\u20102<jats:sup>b<\/jats:sup>) chimeras, but was completely absent for C57BL\/10 (H\u20102<jats:sup>b<\/jats:sup>)\u2192B10.BR (H\u20102<jats:sup>k<\/jats:sup>) chimeras. LCMV\u2010specific cytotoxic effector T cells from B10.BR\u2192C57BL\/10 chimeras were restricted entirely to recipient H\u20102<jats:sup>b<\/jats:sup>. In contrast to the asymmetric cytotoxic T cell response, both types of chimeras developed good primary footpad swelling reactions after local infection, which arose somewhat slower with LCMV than in control of chimeras. The capacity to control infection by <jats:italic>Listeria monocytogenes<\/jats:italic> was excellent for all controls and B10.BR\u2192C57BL\/10 chimeras but apparently absent in C57BL\/10\u2192B10.BR chimeras.<\/jats:p><jats:p>Differentiation of T cell restriction specificity for thymic H\u20102 is apparently most efficient, but it remains unclear whether the observed asymmetry reflects exaggerated immune response regulation in H\u20102\u2010incompatible stem cell\u2010thymus chimeras or differential cross\u2010reactivities between restricting transplantation antigens.<\/jats:p>","DOI":"10.1002\/eji.1830140104","type":"journal-article","created":{"date-parts":[[2007,2,28]],"date-time":"2007-02-28T20:31:04Z","timestamp":1172694664000},"page":"14-23","source":"Crossref","is-referenced-by-count":9,"title":["Anti\u2010viral immune response of allogeneic irradiation bone marrow chimeras: cytotoxic T cell responsiveness depends upon H\u20102 combination and infectious agent"],"prefix":"10.1002","volume":"14","author":[{"given":"Rolf M.","family":"Zinkernagel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshi","family":"Sado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alana","family":"Althage","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoko","family":"Kamisaku","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,16]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"1","volume-title":"Radiation Chimeras","author":"Van Bekkum D. 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