{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T13:15:10Z","timestamp":1756991710767},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,11,16]],"date-time":"2005-11-16T00:00:00Z","timestamp":1132099200000},"content-version":"vor","delay-in-days":7990,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1984,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Plaque\u2010forming cell (PFC) assays were used to investigate <jats:italic>in vitro<\/jats:italic> the immunoregulatory mechanism operating in the self\u2010limiting anti\u2010glomerular basement membrane (GBM) autoantibody response of Brown Norway (BN) rats given HgCl<jats:sub>2<\/jats:sub>. The peak splenic PFC response occurred at day 9; thereafter the response fell sharply and was rarely detected after day 12. In specificity studies, incorporation of soluble GBM in the PFC assays of animals at day 9 had two distinct effects. In some animals the PFC response was inhibited in a dose\u2010dependent fashion; however, in others an augmented number of PFC was observed. Furthermore, addition of GBM to the PFC mixture from certain animals studied at day 12 (or after) revealed large numbers of GBM\u2010specific PFC when originally no GBM\u2010specific PFC had been observed in the standard PFC assay. Sera from such animals, with and without antigen\u2010augmentable PFC, were incorporated in the PFC mixture containing cells taken from day 9 animals. Sera from animals with revealed plaques could inhibit the GBM\u2010specific PFC response of day 9 animals, whereas sera from animals without revealed plaques could not. Thus sera, from BN rats whose own antibody levels were falling, could inhibit the GBM\u2010specific plaque\u2010forming capability of cells from animals at an earlier stage of the autoimmune response and showed the potential importance of humoral factors, putatively anti\u2010idiotypic antibodies, in effecting autoregulation of autoantibody formation in this model.<\/jats:p>","DOI":"10.1002\/eji.1830140516","type":"journal-article","created":{"date-parts":[[2007,2,28]],"date-time":"2007-02-28T21:16:21Z","timestamp":1172697381000},"page":"470-475","source":"Crossref","is-referenced-by-count":44,"title":["Autoregulation of autoantibody synthesis in mercuric chloride nephritis in the Brown Norway rat II. Presence of antigen\u2010augmentable plaque\u2010forming cells in the spleen is associated with humoral factors behaving as auto\u2010anti\u2010idiotypic antibodies"],"prefix":"10.1002","volume":"14","author":[{"given":"Jean Mark","family":"Chalopin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher M.","family":"Lockwood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,16]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830140515"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.150.1.154"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/286164a0"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(83)90258-2"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(83)90227-2"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(77)90065-5"},{"key":"e_1_2_1_8_2","first-page":"599","volume":"14","author":"Cunningham A. 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