{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T11:14:05Z","timestamp":1697886845712},"reference-count":31,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2005,11,16]],"date-time":"2005-11-16T00:00:00Z","timestamp":1132099200000},"content-version":"vor","delay-in-days":7990,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1984,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>It has been reported (<jats:italic>Contemp. Top. Immunobiol<\/jats:italic>. 1974. <jats:italic>3<\/jats:italic>: 41) that allotype\u2010specific T suppressor cells can be induced after monoclonal anti\u2010allotype treatment of neonatal (BALB\/c \u00d7 SJL) F<jats:sub>1<\/jats:sub> (Igh<jats:sup>a\/b<\/jats:sup>) mice. Here we show that (BALB\/c \u00d7 CB20)F<jats:sub>1<\/jats:sub> adult\u2010derived spleen cells (SC) are, by contrast, potently suppressed by monoclonal allotype\u2010specific reagents, (when transferred into irradiated BALB\/c recipients) in the absence of primary T suppressor cell induction. Such suppression is only induced in activated B cells [exposed to lipopolysaccharide or sheep red blood cells (SRBC)], and is probably dependent on the isotype of the anti\u2010allotype sera administered. For example, two independently produced IgG<jats:sub>1<\/jats:sub> monoclonal reagents raised against the Igh\u20101<jats:sup>b<\/jats:sup> allotype were poorly suppressive or nonsuppressive, whereas an IgG<jats:sub>3<\/jats:sub> and an IgG<jats:sub>2a<\/jats:sub> monoclonal antibody induced a 90% suppression of the target allotype in transferred adult SC. It was found that suppression was not due to a depletion of antigen\u2010specific T cell help since: (a) the addition of SRBC\u2010educated T cells did not break suppression and (b) suppressed SC were as good a source of T cell help as normal SC, in the response of virgin or memory B cell (Thy\u20101\u2010depleted) responses to SRBC <jats:italic>in vivo<\/jats:italic>.<\/jats:p><jats:p>Suppression was maintained in suppressed cells which had been rechallenged with SRBC after transfer into a second irradiated recipient, but was not induced in normal SC when these were admixed with an equal number from this suppressed SC population.<\/jats:p><jats:p>These findings point to a possible mechanism for the regulation of B cell expression, through the formation of an antibody\u2010Ig receptor complex at the surface of the B lymphocyte. After complexing the target cell is either deleted or inactivated. The response to SRBC was reduced or ablated for at least 70 days after treatment with a single dose of anti\u2010allotype serum.<\/jats:p>","DOI":"10.1002\/eji.1830141002","type":"journal-article","created":{"date-parts":[[2007,2,28]],"date-time":"2007-02-28T20:56:12Z","timestamp":1172696172000},"page":"865-870","source":"Crossref","is-referenced-by-count":0,"title":["Antibody\u2010mediated allotype suppression in adult mice: The role of antigen, effector isotype and regulatory T cells"],"prefix":"10.1002","volume":"14","author":[{"given":"Elisabeth M. 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