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Both IgM and IgG PFC are inhibited although the number of blasts bearing surface IgG remains unaltered. The IgM and IgG PFC response could be reconstituted to normal levels in cell cultures suppressed by \u03bc\u2010specific antibodies by the addition of supernatants from <jats:italic>in vitro<\/jats:italic> propagated helper T cell clones, or from EL4 lymphoma cells induced with phorbol ester. Interleukin 1\u2010containing P388 supernatant, or recombinant DNA\u2010derived murine interferon\u2010\u03b3, did not reconstitute the PFC response in cell cultures suppressed by \u03bc\u2010specific antibodies, indicating that other factors are responsible for these effects. When spleen cell cultures, <jats:italic>pre\u2010activated<\/jats:italic> with either lipopolysaccharide or monoclonal mouse \u03bc\u2010specific antibodies coupled to Sepharose, were exposed to EL4 supernatants in the presence of soluble \u03bc\u2010specific antibodies, maturation to secretion was inhibited while proliferation was not. The implications of these findings on assay systems for B cell growth and maturation factors are discussed.<\/jats:p>","DOI":"10.1002\/eji.1830141110","type":"journal-article","created":{"date-parts":[[2007,2,28]],"date-time":"2007-02-28T20:56:10Z","timestamp":1172696170000},"page":"1016-1021","source":"Crossref","is-referenced-by-count":13,"title":["Effects of \u03bc\u2010specific antibodies on B cell growth and maturation"],"prefix":"10.1002","volume":"14","author":[{"given":"Tomas","family":"Leanderson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciana","family":"Forni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,16]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830041113"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1974.tb01274.x"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"677","DOI":"10.4049\/jimmunol.115.3.677","volume":"115","author":"Kearney J. 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