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IgG<jats:sub>2a<\/jats:sub>, IgG<jats:sub>2b<\/jats:sub> and IgG<jats:sub>l<\/jats:sub> PFC account for over 90% of all PFC, while the numbers of IgG<jats:sub>3<\/jats:sub>\u2010 and IgA\u2010secreting PFC are lower than in normal animals. These effects appear to be due to both T helper\u2010dependent regulation and to a mitogenic activity associated with the parasites themselves.<\/jats:p>","DOI":"10.1002\/eji.1830150219","type":"journal-article","created":{"date-parts":[[2007,2,28]],"date-time":"2007-02-28T21:41:13Z","timestamp":1172698873000},"page":"201-203","source":"Crossref","is-referenced-by-count":68,"title":["Very large and isotypically atypical polyclonal plaque\u2010forming cell responses in mice infected with <i>Trypanosoma cruzi<\/i>"],"prefix":"10.1002","volume":"15","author":[{"given":"Maria Regina D'Imperio","family":"Lima","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mireille","family":"Joskowicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Coutinho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tereza","family":"Kip","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harvey","family":"Eisen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,16]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-308X(08)60401-7"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1128\/iai.30.2.496-499.1980","volume":"30","author":"Cunningham D. 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