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It was first demonstrated that cloned keyhole limpet hemocyanin (KLH)\u2010specific, major histocompatibility complex (MHC)\u2010restricted T helper (T<jats:sub>h<\/jats:sub>) cells as well as heterogeneous KLH\u2010primed T<jats:sub>h<\/jats:sub> populations were capable of generating PC\u2010specific antibody responses in T\u2010depleted unprimed B cell populations cultured in the presence of PC\u2010KLH. The PC\u2010binding antibody responses generated under these conditions were indistinguishable when assayed for carrier\u2010hapten linkage requirements, immunoglobulin isotype (predominantly IgM) or PC affinity. Further, it was observed that the PC\u2010binding antibodies which were generated in the presence of these two T cell populations expressed equivalently high levels of T15 idiotype. Assaying antibody and idiotype by either enzyme\u2010linked immunosorbent assay or plaque\u2010forming cell assay yielded similar results. Since monoclonal MHC\u2010restricted, KLH\u2010specific T<jats:sub>h<\/jats:sub> cells presumably lack any additional T cell populations, these results argue against an absolute requirement for anti\u2010idiotypic T<jats:sub>h<\/jats:sub> cells in the generation of T15\u2010dominant antibody responses.<\/jats:p>","DOI":"10.1002\/eji.1830150607","type":"journal-article","created":{"date-parts":[[2007,2,28]],"date-time":"2007-02-28T21:52:17Z","timestamp":1172699537000},"page":"564-569","source":"Crossref","is-referenced-by-count":4,"title":["Helper T cell requirements for T15 idiotype expression on phosphorylcholine\u2010specific antibodies"],"prefix":"10.1002","volume":"15","author":[{"given":"Karen S.","family":"Hathcock","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James J.","family":"Kenny","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard J.","family":"Hodes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,16]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830091113"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.148.5.1216"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.144.2.330"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.72.6.2357"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.153.1.1"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830080812"},{"key":"e_1_2_1_8_2","first-page":"386","volume-title":"Isotation, Characterization and Utilization of TLymphocyte Clones","author":"Hodes R. 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