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IgG<jats:sub>l<\/jats:sub> and IgG<jats:sub>2a<\/jats:sub> PFC are the first non\u2010IgM PFC detectable, while IgG<jats:sub>3<\/jats:sub> and IgA PFC appear only around weaning. Adult\u2010type PFC numbers and isotype pattern are present in spleen and BM at 4 and 15 weeks, respectively. Neonatal splenic C3H\/Tif B cells produce non\u2010IgM Ig classes <jats:italic>in vitro<\/jats:italic> in response to polyclonal activation by lipopolysaccharide or by helper T cells. These responses are of low magnitude during the first 2 weeks of life, but both secreted and membrane\u2010bound IgG<jats:sub>1<\/jats:sub> and IgG<jats:sub>3<\/jats:sub> isotypes are detectable already a few days after birth, in a pattern that is identical to that typical of T cell\u2010dependent or independent responses of adult cells. These results indicate full maturity of B cells in \u201cswitch\u201d abilities already from birth, in spite of a general deficiency in terminal maturation. In addition, they demonstrate the complexity of isotype regulation in \u201cbackground\u201d antibody production <jats:italic>in vivo<\/jats:italic>.<\/jats:p>","DOI":"10.1002\/eji.1830151008","type":"journal-article","created":{"date-parts":[[2007,2,28]],"date-time":"2007-02-28T21:34:00Z","timestamp":1172698440000},"page":"1003-1007","source":"Crossref","is-referenced-by-count":6,"title":["Ontogenic development of \u201cnatural\u201d and induced plaque\u2010forming cell isotypes in normal mice"],"prefix":"10.1002","volume":"15","author":[{"given":"Mariana","family":"Bjorklund","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sven","family":"Pettersson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Coutinho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,22]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.138.3.557"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.4049\/jimmunol.114.6.1730","volume":"114","author":"Sidman C. 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