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Cell\u2010free supernatants from the T cell lines demonstrated a marked capacity to enhance IgE\u2010 and IgGa\u2010dependent eosinophil mediated killing of <jats:italic>S. mansoni<\/jats:italic> larvae <jats:italic>in vitro<\/jats:italic>. In addition, supernatants from cloned T cells stimulated with concanavalin A or specific antigen, or unstimulated, enhanced IgE\u2010dependent eosinophil\u2010mediated helminthotoxicity. The enhancing activity in both cases was very heat\u2010stable (100\u00b0C, 10 min). We also found that clone\u2010derived supernatants enhance eosinophil peroxidase release upon stimulation with homologous IgE and anti\u2010IgE as well as inducing a more delayed spontaneous release of peroxidase. In view of the established thymus dependency for the development of immunity to schistosomiasis in the rat, the availability of these <jats:italic>s. mansoni<\/jats:italic>\u2010specific cloned T cells has enabled the relationship between eosinophils, lymphocytes and anaphylactic antibodies to be examined more closely.<\/jats:p>","DOI":"10.1002\/eji.1830151218","type":"journal-article","created":{"date-parts":[[2007,2,28]],"date-time":"2007-02-28T21:49:46Z","timestamp":1172699386000},"page":"1244-1250","source":"Crossref","is-referenced-by-count":9,"title":["Eosinophil activation by lymphokines and T cell clone products in the rat"],"prefix":"10.1002","volume":"15","author":[{"given":"Monica","family":"Veith","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f6el","family":"Pestel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvie","family":"Loiseau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monique","family":"Capron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9","family":"Capron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,22]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/256727a0"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830080211"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"628","DOI":"10.4049\/jimmunol.122.2.628","volume":"122","author":"Anwar A. 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