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Our results show that these drugs suppress the anti\u2010\u03bc\u2010induced human B cell proliferation and interfere with the early events of the B cell activation in a dose\u2010dependent fashion. This suppression correlates with a marked decrease in anti\u2010\u03bc\u2010induced <jats:sup>45<\/jats:sup>Ca<jats:sup>2+<\/jats:sup> uptake. Calcium channel\u2010blocking drugs inhibit the anti\u2010\u03bc\u2010induced uridine incorporation and the appearance of the activation marker defined by the 4F2 monoclonal antibody. Calcium channel\u2010blocking drugs also inhibit B cell proliferation induced by the costimulation with anti\u2010\u03bc antibody and B cell growth factor (BCGF). However, this inhibition takes place at the early (anti\u2010\u03bc\u2010dependent) stage of B cell activation: the BCGF\u2010dependent proliferation of <jats:italic>in vitro<\/jats:italic> anti\u2010\u03bc\u2010activated B cells is only marginally inhibited. Finally the proliferation of Epstein\u2010Barr virus\u2010infected B cell lines is resistant to the effect of calcium channel\u2010blocking drugs.<\/jats:p>","DOI":"10.1002\/eji.1830160210","type":"journal-article","created":{"date-parts":[[2007,2,28]],"date-time":"2007-02-28T23:06:10Z","timestamp":1172703970000},"page":"162-167","source":"Crossref","is-referenced-by-count":18,"title":["Human B cell activation: Selective sensitivity of the early stages to calcium channel\u2010blocking drugs"],"prefix":"10.1002","volume":"16","author":[{"given":"Bernard","family":"Dugas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aim\u00e9","family":"Vazquez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Fran\u00e7ois","family":"Delfraissy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Philippe","family":"G\u00e9rard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie\u2010Th\u00e9r\u00e8se","family":"Rannou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Galanaud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,17]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.122.4.823"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.155.5.1523"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"176","DOI":"10.4049\/jimmunol.132.1.176","volume":"132","author":"Muraguchi A.","year":"1984","journal-title":"J. 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