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Thus, proliferative T cell responses were obtained after stimulation with allogeneic LPS blasts, concanavalin A (Con A) blasts, normal spleen cells or peritoneal macrophages while only LPS and Con A blasts were competent syngeneic stimulators. The cytolytic activity of T cells stimulated with allogeneic LPS blasts was H\u20102 specific, while that of T cells stimulated with syngeneic LPS blasts was often completely nonspecific, and higher for LPS than for Con A blast target cells. In other experiments, \u201cself\u201d H\u20102K\u2010and I\u2010A\u2010specific cytotoxic T cells were obtained, without apparent reasons for the development of either type of cytolytic cells. Stimulation of Lyt\u20102<jats:sup>\u2212<\/jats:sup> T cells with syngeneic LPS blasts led to the generation of T helper effector cells which induced normal B cell proliferation in an H\u20102 restricted manner. This restriction was overcome, the proliferative responses were augmented and plaque\u2010forming cell responses generated, through addition of Con A to the cultures. The results imply the ability of B blasts to induce stimulation of syngeneic T cells, and generation of effector cells displaying cytolytic and helper activity. This phenomenon might play a role in the regulation of the immune system.<\/jats:p>","DOI":"10.1002\/eji.1830160502","type":"journal-article","created":{"date-parts":[[2007,2,28]],"date-time":"2007-02-28T23:25:46Z","timestamp":1172705146000},"page":"471-477","source":"Crossref","is-referenced-by-count":6,"title":["Effector functions and specificities of normal murine T cells stimulated by syngeneic blasts"],"prefix":"10.1002","volume":"16","author":[{"given":"Mariana","family":"Bj\u00f6rklund","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Beretta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Coutinho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Gullberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,17]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.4049\/jimmunol.110.4.1090","volume":"100","author":"Howe M. 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