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We found that the following immune phenomena were independent of antibodies: (a) the generation of virus\u2010specific cytotoxic T cells; (b) the footpad swelling response against locally injected LCMV; (c) natural killer cell activity basic levels or after LCMV or poly(1). poly(C) stimulation; (d) immunopathologically mediated LCM after primary intracerebral inoculation; (e) immunological memory in LCMV\u2010immune mice assessed by immune protection against LCM after intracerebrally injected virus or as resistance against the local footpad swelling response to LCMV. This study demonstrates that humoral immunity plays no crucial role in immune protection and immunopathology in murine LCMV infection and suggests that protective memory T cell function is B cell and antibody independent.<\/jats:p>","DOI":"10.1002\/eji.1830160807","type":"journal-article","created":{"date-parts":[[2007,2,28]],"date-time":"2007-02-28T23:35:45Z","timestamp":1172705745000},"page":"913-917","source":"Crossref","is-referenced-by-count":16,"title":["Immunity to lymphocytic choriomeningitis virus in B cell\u2010depleted mice: evidence for B cell and antibody\u2010independent protection by memory T cells"],"prefix":"10.1002","volume":"16","author":[{"given":"Andreas","family":"Cerny","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ambros W.","family":"Huegin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Sutter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hervi\u00e9","family":"Bazin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans H.","family":"Hengartner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rolf M.","family":"Zinkernagel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,9]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"167","volume":"12","author":"Rowe W. 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