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Nude\u2010xid mice have normal numbers of hematopoietic colony forming units (CFU\u2010s) but lack two early pre\u2010B cell markers: susceptibility to transformation by Abelson murine leukemia virus (A\u2010MuLV) and production of cytoplasmic \u03bc (C\u03bc) heavy chain. Thus, there is a defect in lymphocyte development prior to or early in pre\u2010B cell differentiation but after hematopoietic stem cell formation. The monoclonal reagents DNL 1.9, 14.8 and RA3\u20133A1\/6.1, which react with the surface protein B220 (Ly 5) on pro\u2010B, C\u03bc<jats:sup>\u2212<\/jats:sup> pre\u2010B, C\u03bc<jats:sup>+<\/jats:sup> pre\u2010B, and surface Ig<jats:sup>+<\/jats:sup> B cells, revealed the presence of positive cells in nude\u2010xid mice. The bone marrow of nude\u2010xid mice contains more B220<jats:sup>+<\/jats:sup> cells than C\u03bc<jats:sup>+<\/jats:sup> cells. Our data suggest that the developmental block in these mice occurs at the earliest identifiable step in the B lymphocyte lineage, after the appearance of B220<jats:sup>+<\/jats:sup> C\u03bc<jats:sup>\u2212<\/jats:sup> pro\u2010 B cells, but before the differentiation of C\u03bc\u2010bearing (pre\u2010B) cells.<\/jats:p>","DOI":"10.1002\/eji.1830160916","type":"journal-article","created":{"date-parts":[[2007,2,28]],"date-time":"2007-02-28T23:42:03Z","timestamp":1172706123000},"page":"1125-1130","source":"Crossref","is-referenced-by-count":25,"title":["Early arrest of B cell development in nude, X\u2010linked immune\u2010deficient mice"],"prefix":"10.1002","volume":"16","author":[{"given":"Domna","family":"Karagogeos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naomi","family":"Rosenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry H.","family":"Wortis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,17]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.155.3.903"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.155.3.924"},{"key":"e_1_2_1_4_2","first-page":"316","volume":"50","author":"Boersma W. 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