{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T22:04:10Z","timestamp":1770501850348,"version":"3.49.0"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,11,17]],"date-time":"2005-11-17T00:00:00Z","timestamp":1132185600000},"content-version":"vor","delay-in-days":6895,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1987,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Brown\u2010Norway (BN) rats injected with HgCl<jats:sub>2<\/jats:sub> have been previously shown to develop a variety of autoimmune abnormalities. The susceptibility of BN rats is genetically controlled, and Lewis rats bearing a different RT1 haplotype are resistant. It will be shown in the present study that the number of MRC OX\u20108<jats:sup>+<\/jats:sup> (suppressor\/cytotoxic) cells increases in the spleen and lymph nodes of Lewis rats injected with HgCl<jats:sub>2<\/jats:sub>. The responsiveness to T cell mitogens and to alloantigens is concomitantly inhibited. Spleen cells from Lewis rats injected with HgCl<jats:sub>2<\/jats:sub> fail to induce a local graft\u2010<jats:italic>vs<\/jats:italic>.\u2010host reaction. Data presented show that MRC OX\u20108<jats:sup>+<\/jats:sup> cells are involved in the immunosuppression in Lewis rats treated with HgCl<jats:sub>2<\/jats:sub>. Furthermore, lymph node cells and MRC OX\u20108<jats:sup>+<\/jats:sup> cells from these rats are able to inhibit the normal mixed lymphocyte reaction indicating that suppression is active. Thus, HgCl<jats:sub>2<\/jats:sub> is able to trigger immune dysregulation leading either to autoimmunity or to immunosuppression depending upon the genetic background of the rat strain tested.<\/jats:p>","DOI":"10.1002\/eji.1830170109","type":"journal-article","created":{"date-parts":[[2007,2,28]],"date-time":"2007-02-28T23:34:41Z","timestamp":1172705681000},"page":"49-54","source":"Crossref","is-referenced-by-count":44,"title":["HgCl<sub>2<\/sub> induces nonspecific immunosuppression in Lewis rats"],"prefix":"10.1002","volume":"17","author":[{"given":"Lucette","family":"Pelletier","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R\u00e9gine","family":"Pasquier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e9rome","family":"Rossert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Druet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,17]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"173","volume":"28","author":"Sapin C.","year":"1977","journal-title":"Clin. Exp. Immunol."},{"key":"e_1_2_1_3_2","first-page":"777","volume":"129","author":"Druet P.","year":"1978","journal-title":"Ann. Inst. Pasteur (Paris)"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"699","DOI":"10.4049\/jimmunol.126.2.699","volume":"126","author":"Prouvost\u2010Danon A.","year":"1981","journal-title":"J. Immunol."},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830070605"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00364205"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830100510"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0019-2791(69)90178-5"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(77)90266-5"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(77)90016-3"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830150509"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830120716"},{"key":"e_1_2_1_13_2","doi-asserted-by":"crossref","first-page":"2548","DOI":"10.4049\/jimmunol.137.8.2548","volume":"137","author":"Pelletier L.","year":"1986","journal-title":"J. Immunol."},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.154.2.459"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(84)90012-6"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830140515"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.157.2.755"},{"key":"e_1_2_1_18_2","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.4049\/jimmunol.123.3.1362","volume":"123","author":"Rup B. J.","year":"1979","journal-title":"J. Immunol."},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/141.4.488"},{"key":"e_1_2_1_20_2","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.4049\/jimmunol.125.3.1269","volume":"125","author":"Reinherz E. L.","year":"1980","journal-title":"J. Immunol."},{"key":"e_1_2_1_21_2","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.4049\/jimmunol.122.4.1310","volume":"122","author":"Kirchner H.","year":"1979","journal-title":"J. Immunol."},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(84)90126-9"},{"key":"e_1_2_1_23_2","first-page":"146","volume":"8","author":"Huskisson E. C.","year":"1981","journal-title":"J. Rheumatol."},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(84)90015-1"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(81)90079-4"},{"key":"e_1_2_1_26_2","doi-asserted-by":"crossref","first-page":"136","DOI":"10.4049\/jimmunol.136.1.136","volume":"136","author":"Nagata N.","year":"1986","journal-title":"J. Immunol."},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(77)92297-8"},{"key":"e_1_2_1_28_2","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.4049\/jimmunol.120.3.1006","volume":"120","author":"Lipsky P. E.","year":"1978","journal-title":"J. Immunol."},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(86)90217-5"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(80)91677-3"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1984.111"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1961.04020070039007"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-85-1-82"},{"key":"e_1_2_1_34_2","first-page":"273","volume":"20","author":"Sorrell T. C.","year":"1975","journal-title":"Clin. Exp. Immunol."},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2900010207"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(82)90183-0"}],"container-title":["European Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feji.1830170109","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.1830170109","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T08:28:35Z","timestamp":1697876915000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eji.1830170109"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,1]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1987,1]]}},"alternative-id":["10.1002\/eji.1830170109"],"URL":"https:\/\/doi.org\/10.1002\/eji.1830170109","archive":["Portico"],"relation":{},"ISSN":["0014-2980","1521-4141"],"issn-type":[{"value":"0014-2980","type":"print"},{"value":"1521-4141","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,1]]}}}