{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:41:36Z","timestamp":1786977696871,"version":"build-2736575974"},"reference-count":46,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,11,17]],"date-time":"2005-11-17T00:00:00Z","timestamp":1132185600000},"content-version":"vor","delay-in-days":6895,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1987,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    We established several H\u20102\u2010restricted lymphocytic choriomeningitis virus (LCMV)\u2010specific cytotoxic T cell clones from spleens of virus\u2010primed C57BL\/6 or C57BL\/10 (H\u20102\n                    <jats:sup>b<\/jats:sup>\n                    ) and B10.BR (H\u20102\n                    <jats:sup>k<\/jats:sup>\n                    ) mice and from allogeneic C57BL\/10\u2192B10.BR and B10.BR\u2192C57BL\/10 bone marrow chimeras. Two T cell clones of H\u20102\n                    <jats:sup>b<\/jats:sup>\n                    origin and restricted to H\u20102\n                    <jats:sup>b<\/jats:sup>\n                    , 3 of H\u20102\n                    <jats:sup>k<\/jats:sup>\n                    origin and restricted to H\u20102\n                    <jats:sup>k<\/jats:sup>\n                    were compared with two clones each derived from the two types of chimeras. Their surface phenotype was found to be Lyt\u20102\n                    <jats:sup>+<\/jats:sup>\n                    , L3\/T4\n                    <jats:sup>\u2212<\/jats:sup>\n                    and KJ16\u2010133\n                    <jats:sup>+<\/jats:sup>\n                    (2 of 9). Clones from chimeras expressed bone marrow donor H\u20102 and are restricted to the recipient H\u20102.\n                  <\/jats:p>\n                  <jats:p>\n                    H\u20102\n                    <jats:sup>k<\/jats:sup>\n                    \u2010restricted clones were all specific for K\n                    <jats:sup>k<\/jats:sup>\n                    whereas all H\u20102\n                    <jats:sup>b<\/jats:sup>\n                    \u2010restricted clones were specific for D\n                    <jats:sup>b<\/jats:sup>\n                    . These restriction specificities could be further defined by the blocking activity of various monoclonal anti\u2010H\u20102 antibodies. Interestingly the anti\u2010H\u20102D\n                    <jats:sup>b<\/jats:sup>\n                    antibodies blocked the restricted virus\u2010specific killing activity of the clones derived B10.BR\u2192C57BL\/10 chimeras much more effectively than the activity of the clones derived from conventional H\u20102\n                    <jats:sup>b<\/jats:sup>\n                    mice.\n                  <\/jats:p>\n                  <jats:p>\n                    The various clones differed with respect to their fine specificity for LCMV strains. The 3 clones of conventional B10.BR origin only recognized LCMV\u2010WE but not LCMV\u2010Armstrong, Aggressive or Docile; H\u20102\n                    <jats:sup>b<\/jats:sup>\n                    \u2010restricted conventional clones recognized target cells infected with all LCMV strains except LCMV\u2010UBC\u2010Docile; the T cell clones from the bone marrow chimeras recognized with one exception all LCMV strains tested.\n                  <\/jats:p>","DOI":"10.1002\/eji.1830170202","type":"journal-article","created":{"date-parts":[[2007,2,28]],"date-time":"2007-02-28T19:31:01Z","timestamp":1172691061000},"page":"159-166","source":"Crossref","is-referenced-by-count":50,"title":["Characterization of virus\u2010specific cytotoxic T cell clones from allogeneic bone marrow chimeras"],"prefix":"10.1002","volume":"17","author":[{"given":"Hanspeter","family":"Pircher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrg","family":"Baenziger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Schilham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshi","family":"Sado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoko","family":"Kamisaku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Hengartner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf M.","family":"Zinkernagel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,11,17]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"56","volume":"19","author":"Blanden R. 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