{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T10:25:34Z","timestamp":1770719134565,"version":"3.49.0"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,11,17]],"date-time":"2005-11-17T00:00:00Z","timestamp":1132185600000},"content-version":"vor","delay-in-days":6895,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1987,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Spontaneous autoimmune disease in NZB and (NZB \u00d7 NZW)F<jats:sub>1<\/jats:sub> (B\/W) mice is associated with a spectrum of lymphoproliferative abnormalities, but the relationship between autoimmunity and lymphoproliferation is poorly understood. Lymphomas occur commonly in NZB mice, but they appear to be rare in B\/W mice, perhaps because B\/W mice die of murine lupus before the lymphomas are evident. We recently reported that autoimmune disease in B\/W mice could be reversed by weekly treatment with monoclonal antibodies to the L3T4 antigen on \u201chelper\/inducer\u201d T cells. This has enabled us to examine the evolution of lymphoproliferation in B\/W mice that survive beyond the usual life span, both in long\u2010term survivors of treatment with anti\u2010L3T4 and in the occasional B\/W mouse that spontaneously survives beyond 1 year of age. We find that all of these mice develop marked proliferation of a distinct subpopulation of B cells that express the Ly\u20101 antigen in low density. These Ly\u20101<jats:sup>+<\/jats:sup> B cells account for a 2\u201010\u2010fold increase in the number of splenic, lymph node and peripheral blood lymphocytes. The Ly\u20101 B cells in individual mice are restricted in their expression of immunoglobulin light chains, suggesting a clonal origin. NZB mice develop similar proliferation of Ly\u20101 B cells, suggesting that this is due to underlying genetic and\/or viral factors in NZB and B\/W mice, and that it is not the result of treatment with anti\u2010L3T4. Although recent studies have implicated Ly\u20101 B cells in the production of autoantibodies, proliferation of Ly\u20101 B cells in B\/W mice was not associated with production of anti\u2010DNA antibodies or with any paraprotein.<\/jats:p>","DOI":"10.1002\/eji.1830170612","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T00:40:02Z","timestamp":1172709602000},"page":"809-814","source":"Crossref","is-referenced-by-count":42,"title":["Proliferation of Ly\u20101 B cells in autoimmune NZB and (NZB \u00d7 NZW)F<sub>1<\/sub> mice"],"prefix":"10.1002","volume":"17","author":[{"given":"David","family":"Wofsy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy Y.","family":"Chiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,17]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"247","volume-title":"Textbook of Immunopathology","author":"Howie J. 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