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These proliferative response of nickel\u2010specific TLC required the presence of antigen\u2010presenting cells (APC) and were restricted by HLA class II molecules. All TLC recognized nickel presented by APC from epidermal skin. Remarkably, 5 out of 8 nickel\u2010specific TLC exclusively recognized nickel when presented by these skin\u2010specific APC whereas 3 out of these 8 clones could also recognize nickel presented by APC from peripheral blood. The critical APC within the fractions of epidermal cells and peripheral blood appeared to belong to the family of dendritic cells, <jats:italic>i.e.<\/jats:italic> Langerhans cells and circulating dendritic cells, respectively.<\/jats:p>","DOI":"10.1002\/eji.1830170620","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T00:40:02Z","timestamp":1172709602000},"page":"861-865","source":"Crossref","is-referenced-by-count":75,"title":["Nickel\u2010specific T lymphocyte clones derived from allergic nickel\u2010contact dermatitis lesions in man: heterogeneity based on requirement of dendritic antigen\u2010presenting cell subsets"],"prefix":"10.1002","volume":"17","author":[{"given":"Martien L.","family":"Kapsenberg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Res","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan D.","family":"Bos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annelies","family":"Schootemijer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcel B. 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