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This direct stimulation by nickel was not restricted by major histocompatibility complex\u2010encoded molecules, since antibodies against HLA class I and I1 molecules did not block nickel\u2010specific proliferation. Proliferation of other nickel\u2010specific TLC was dependent on the presence of APC and was diversely restricted by HLA class I1 molecules. With one exception, the restriction determinants were present on HLA\u2010DR and HLA\u2010DQ molecules. Four TLC recognized nickel in association with subtypes of these serologically defined molecules. Five TLC seemed to recognize nickel in the context of highly unusual restriction determinants, since their restrictions could not be explained by the function of single polymorphic HLA class I1 epitopes. The absence of HLA class I1 restrictions and the occurrence of deviant HLA class I1 restrictions in part of the nickel\u2010specific TLC are suggested to result from direct interactions of nickel with critical immune response molecules.<\/jats:p>","DOI":"10.1002\/eji.1830180702","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T05:21:14Z","timestamp":1172726474000},"page":"977-982","source":"Crossref","is-referenced-by-count":39,"title":["Direct and indirect nickel\u2010specific stimulation of T lymphocytes from patients with allergic contact dermatitis to nickel"],"prefix":"10.1002","volume":"18","author":[{"given":"Martien L.","family":"Kapsenberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tineke Van Der","family":"Pouw\u2010Kraan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank E.","family":"Stiekema","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annelies","family":"Schootemeijer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan D.","family":"Bos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,11,22]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(86)90111-8"},{"key":"e_1_2_1_3_2","first-page":"39","volume-title":"Occupational and industrial dermatology","author":"Polak L.","year":"1982"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830170620"},{"key":"e_1_2_1_5_2","first-page":"211","volume":"16","author":"Karvonen J.","year":"1984","journal-title":"Ann. 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