{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T03:47:45Z","timestamp":1770695265835,"version":"3.49.0"},"reference-count":17,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2005,11,22]],"date-time":"2005-11-22T00:00:00Z","timestamp":1132617600000},"content-version":"vor","delay-in-days":6353,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1988,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Natural and synthetic immunomodulators that increase nonspecific resistance to infection are also known to induce interleukin 1 (IL1) production. Previous studies have demonstrated a protective effect of recombinant human IL1\u03b2 against death from infection caused by <jats:italic>Pseudomonas aeruginosa.<\/jats:italic> In the present study we investigated the effect of IL 1\u03b2 or IL 1\u03b1 on the survival of neutropenic mice with a lethal <jats:italic>Candida albicans<\/jats:italic> infection. Mice with cyclophosphamide\u2010induced neutropenia were injected with 3 \u00d7 10<jats:sup>5<\/jats:sup> <jats:italic>C. albicans<\/jats:italic> i.v. When 80 ng IL 1\u03b2 was given as a single i.p. injection 24 h before the infection, survival compared to that in control animals was as follows: 100% vs. 97% at 24 h, 83% <jats:italic>vs.<\/jats:italic> 70% at 48 h and 70% <jats:italic>vs.<\/jats:italic> 23% at 72 h after the infection (p&lt;0.01). The effect of IL1 was also apparent when it was given 1\/2 h before or 6 h after the infection. The results obtained with 80 ng IL 1\u03b1 given at 24 h before infection were similar to that obtained with IL 1\u03b2. The numbers of <jats:italic>Candida<\/jats:italic> cultured from the blood, liver, spleen, and kidney were not significantly different in IL 1\u03b2\u2010treated and control animals. Passive transfer of serum obtained from mice pretreated with IL 1 to recipient mice did not provide protection against a subsequent lethal candidal infection. In conclusion, the present study demonstrates that IL 1\u03b2 and IL 1\u03b1 prolong survival in neutropenic mice with a lethal <jats:italic>C. albicans<\/jats:italic> infection.<\/jats:p>","DOI":"10.1002\/eji.1830180728","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T05:21:14Z","timestamp":1172726474000},"page":"1143-1146","source":"Crossref","is-referenced-by-count":78,"title":["Protection of neutropenic mice from lethal Candida albicans infection by recombinant interleukin 1"],"prefix":"10.1002","volume":"18","author":[{"given":"Jan W. 'T","family":"Van Wout","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos W. M. Der","family":"Van Meer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Barza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles A.","family":"Dinarello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,22]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"S13","volume":"77","author":"Bodey G. P.","year":"1984","journal-title":"Am. J. 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