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The ability of LFA\u20101<jats:sup>\u2212<\/jats:sup> T lymphocytes to provide antigen\u2010specific help for HLA<jats:sup>\u2212<\/jats:sup>identical LFA\u20101<jats:sup>+<\/jats:sup> B lymphocytes was reduced while their antigen\u2010specific activation was normal. Antigen\u2010independent conjugate formation between resting, nonactivated LFA\u20131<jats:sup>\u2212<\/jats:sup> T lymphocytes and LFA\u20101<jats:sup>+<\/jats:sup> B lymphocytes was impaired while LFA\u20101<jats:sup>\u2212<\/jats:sup>B lymphocytes bound LFA\u20101<jats:sup>+<\/jats:sup> T lymphocytes normally. Conjugate formation of activated LFA\u20101<jats:sup>\u2212<\/jats:sup> T lymphocytes was mostly mediated by the CD2\u2010LFA\u20103 adhesion pathway while the ICAM\u20101 molecule, a ligand of LFA\u20101, had no function. These results demonstrate that LFA\u20101 plays a major role in the cognate interaction between helper T lymphocytes and B lymphocytes that cannot be mediated instead by CD2 or other molecules on resting T lymphocytes.<\/jats:p>","DOI":"10.1002\/eji.1830180813","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T07:20:02Z","timestamp":1172733602000},"page":"1229-1234","source":"Crossref","is-referenced-by-count":40,"title":["The role of lymphocyte function\u2010associated antigen 1 (LFA\u20101) in the adherence of T lymphocytes to B lymphocytes"],"prefix":"10.1002","volume":"18","author":[{"given":"Fabienne","family":"Mazerolles","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Lumbroso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivia","family":"Lecomte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7oise","family":"Le Deist","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alain","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,22]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1982.tb01064.x"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830130305"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.158.6.1785"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.160.6.1901"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(87)90215-7"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830170318"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.me.38.020187.001135"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112251"},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"3198","DOI":"10.4049\/jimmunol.136.9.3198","volume":"136","author":"Fischer A.","year":"1986","journal-title":"J. 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