{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T15:45:11Z","timestamp":1762271111675},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2005,11,22]],"date-time":"2005-11-22T00:00:00Z","timestamp":1132617600000},"content-version":"vor","delay-in-days":6322,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1988,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>During generalized immune responses such as the acute phase of graft\u2010vs.\u2010host reaction (GvHR) or many systemic viral infections the macrophage\u2010monocyte system of mice is activated as demonstrated by their increased bactericidal capacity against <jats:italic>Listeria monocytogenes.<\/jats:italic> To study the effect of interferon (IFN)\u2010\u03b3 in maintainance of macrophage activity, lymphocytic choriomeningitis virus (LCMV) primed C57BW6 mice or (C57BL\/10 \u00d7 B10.BR) F<jats:sub>1<\/jats:sub> mice undergoing a GvHR were treated with polyclonal specific sheep anti\u2010IFN\u2010\u03b3 antiserum. In both cases injection of anti\u2010IFN\u2010\u03b3 resulted in inhibition of the stimulatory effects on macrophages as detected by reduced bactericidal activity when compared to mice treated with normal serum. Treatment with a polyclonal sheep anti\u2010IFN\u2010\u03b1, \u03b2 antiserum on the other hand did not interfere with the activation status of the macrophages. The findings suggest that IFN\u2010\u03b1 is produced both early in a GvHR and during the acute phase of an systemic infection with LCMV, and that it is involved in <jats:italic>in vivo<\/jats:italic> modulation of the increased activity of mononuclear phagocytes in immunologically stimulated mice.<\/jats:p>","DOI":"10.1002\/eji.1830180822","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T07:20:02Z","timestamp":1172733602000},"page":"1295-1298","source":"Crossref","is-referenced-by-count":8,"title":["Increased bactericidal macrophage activity induced by immunological stimuli is dependent on interferon (IFN)\u2010\u0393"],"prefix":"10.1002","volume":"18","author":[{"given":"Thomas P.","family":"Leist","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rainer","family":"Heuchel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rolf M.","family":"Zinkernagel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,22]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.02.040184.001435"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830141019"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.21.7404"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-196906000-00005"},{"key":"e_1_2_1_6_2","first-page":"15","volume":"18","author":"Allison A. 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