{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:02:48Z","timestamp":1762160568589},"reference-count":33,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2005,11,22]],"date-time":"2005-11-22T00:00:00Z","timestamp":1132617600000},"content-version":"vor","delay-in-days":6291,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1988,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Human T lymphocytes infiltrating the liver in chronic active hepatitis B (CAH\u2010B) and primary biliary cirrhosis were isolated from liver biopsy cores, cloned by limiting dilution technique and expanded <jats:italic>in vitro.<\/jats:italic> Phenotypic and functional analysis demonstrates that this tissue infiltrate represents a heterogeneous cell population. However, when compared to peripheral blood lymphocytes of the same patients, a marked enrichment for T8 cytotoxic T cells was found to exist at a local site in both types of chronic liver disease. These data provide support for the notion that liver cell injury in CAH\u2010B and PBC may be mediated by a common immunologic mechanism likely executed by cells of the T lineage.<\/jats:p>","DOI":"10.1002\/eji.1830180922","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T07:19:35Z","timestamp":1172733575000},"page":"1447-1452","source":"Crossref","is-referenced-by-count":51,"title":["Clonal analysis of human T lymphocytes infiltrating the liver in chronic active hepatitis B and primary biliary cirrhosis"],"prefix":"10.1002","volume":"18","author":[{"given":"Stefan C.","family":"Meuer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich","family":"Moebius","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael M.","family":"Manns","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans P.","family":"Dienes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guiliano","family":"Ramadori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg","family":"Hess","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thierry","family":"Hercend","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl\u2010Hermann Meyer Zum","family":"Buschenfelde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,22]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(68)90710-1"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1040643"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1040644"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1040645"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(83)90022-7"},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0016-5085(83)80082-1","volume":"85","author":"Colucci G.","year":"1983","journal-title":"Gastroenterology"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840030303"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"2773","DOI":"10.4049\/jimmunol.129.6.2773","volume":"129","author":"Mondelli M.","year":"1982","journal-title":"J. Immunol."},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.23.12.1029"},{"key":"e_1_2_1_11_2","volume-title":"Liver biopsy interpretation","author":"Scheuer P. J.","year":"1983"},{"key":"e_1_2_1_12_2","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/S0016-5085(19)35377-6","volume":"37","author":"Sherlock S.","year":"1982","journal-title":"Gastroenterology"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197309272891306"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840020102"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(86)80015-0"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.181845"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.14.4395"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.76.8.4061"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111794"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6981845"},{"key":"e_1_2_1_21_2","first-page":"571","volume":"5","author":"Dienes H. P.","year":"1983","journal-title":"J. Histochem."},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.158.2.571"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/301158a0"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.5.1509"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830161227"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(86)80493-7"},{"key":"e_1_2_1_27_2","doi-asserted-by":"crossref","first-page":"539","DOI":"10.4049\/jimmunol.139.2.539","volume":"139","author":"Ferrari C.","year":"1987","journal-title":"J. Immunol."},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)91108-5"},{"key":"e_1_2_1_29_2","first-page":"185","volume":"131","author":"Meuer S. C.","year":"1983","journal-title":"J. Immunol."},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830140914"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830151011"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(84)90039-4"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/326298a0"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.158.3.988"}],"container-title":["European Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feji.1830180922","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.1830180922","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T16:01:45Z","timestamp":1695657705000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eji.1830180922"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,9]]},"references-count":33,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1988,9]]}},"alternative-id":["10.1002\/eji.1830180922"],"URL":"https:\/\/doi.org\/10.1002\/eji.1830180922","archive":["Portico"],"relation":{},"ISSN":["0014-2980","1521-4141"],"issn-type":[{"value":"0014-2980","type":"print"},{"value":"1521-4141","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,9]]}}}