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Treatment with anti\u2010Thy\u20101 <jats:italic>in vivo<\/jats:italic> immediately prior to transfer abrogates the suppression, while depleting B cells has no effect.The <jats:italic>in siru<\/jats:italic> induced tolerance can be prevented by treatment with monoclonal antibodies to the Ly\u20101 or L3T4 molecules either prior to or post tolerization. Anti\u2010Ly\u20102 treatment has no effect. In the transfer, again treatment of donors with anti\u2010L3T4 prior to transfer prevents the demonstration of suppression in the recipients, while anti\u2010Ly\u20102 does not affect suppression. These data suggest that the suppression is being mediated either by a CD4<jats:sup>\u2212<\/jats:sup> T suppressor cell or a CD4 suppressor inducer cell. 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