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Both the intracellular and secreted forms of the \u03bc chains were similarly truncated. The membrane and the secreted forms of \u03bc mRNAs were shorter than normal. The cDNAs contained a leader sequence, followed by about one third of a variable region (V<jats:sub>H<\/jats:sub>), then by the constant region (C<jats:sub>\u03bc<\/jats:sub>). Interruption of the variable region took place near the end of the framework region 1 (FR1) in Ly47 and JBL2, and within the complementarity determining region 1 (CDR1) in Ly 91. In the three lines, the joining between V<jats:sub>H<\/jats:sub> and C<jats:sub>\u03bc<\/jats:sub> maintained the normal open reading frame throughout the variable and constant regions.<\/jats:p>","DOI":"10.1002\/eji.1830181003","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T05:07:48Z","timestamp":1172725668000},"page":"1485-1490","source":"Crossref","is-referenced-by-count":12,"title":["BURKITT'S LYMPHOMA CELL LINES PRODUCING TRUNCATED P IMMUNOGLOBULIN HEAVY CHAINS LACKING PART OF THE VARIABLE REGION"],"prefix":"10.1002","volume":"18","author":[{"given":"Michel","family":"Cogn\u00e9","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir","family":"Mounir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Louis","family":"Preu\u010fhomme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francois","family":"Nau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Guglielmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,11,22]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/312418a0"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/304355a0"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1979.tb00302.x"},{"key":"e_1_2_1_5_2","unstructured":"Alexander A. 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