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Recently this strain has further been shown to harbor retrovirus\u2010related sequences (endogenous virus no. 22, <jats:italic>ev22<\/jats:italic>) absent in healthy control strains. To determine the number of genes responsible for SAT\u2010associated immunodysregulation and to unravel possible ev22 associations, we analyzed the above immune and endocrine parameters in F<jats:sub>1<\/jats:sub> hbrids and backcrosses of the autoimmune OS <jats:italic>B<jats:sup>15<\/jats:sup>B<jats:sup>15<\/jats:sup><\/jats:italic> with healthy inbred CB <jats:italic>B<jats:sup>12<\/jats:sup>B<jats:sup>12<\/jats:sup><\/jats:italic> chickens.<\/jats:p><jats:p>OS\u2010like T cell hyperproliferation and IL2 hypersecretion in response to both con\u2010canavalin A and phytohemagglutinin were transmitted as autosomal dominant traits and co\u2010segregated in backcross animals. <jats:italic>In vivo<\/jats:italic> hyporesponse of the OS to the cor\u2010ticosterone\u2010inducing effect of cytokine preparations was inherited dominantly and the elevated CBG serum levels recessively. None of these traits appeared to be major histocompatibility complex (MHC) linked. However, while T cell abnormalities and elevated CBG serum levels were not associated with the autosomal <jats:italic>ev22<\/jats:italic> locus, <jats:italic>in vivo<\/jats:italic> hyporesponsiveness to glucocortocoid\u2010inducing cytokines co\u2010segregated with this OS\u2010specific provirus.<\/jats:p><jats:p>These results add to the concept of SAT as a polyetiological and plurigenetic disease and do not support our previous hypothesis that T cell hyperreactivity and immunoen\u2010docrine dysfunction might be functionally related.<\/jats:p>","DOI":"10.1002\/eji.1830181005","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T05:07:48Z","timestamp":1172725668000},"page":"1499-1506","source":"Crossref","is-referenced-by-count":13,"title":["GENETIC ANALYSIS OF EXTRATHYROIDAL FEATURES OF OBESE STRAIN (OS) CHICKENS WITH SPONTANEOUS AUTOIMMUNE THYROIDITIS"],"prefix":"10.1002","volume":"18","author":[{"given":"Guido","family":"Kroemer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinhard","family":"Faessler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karel","family":"H\u00e1la","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guenther","family":"Boeck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konrad","family":"Schauenstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans\u2010Peter","family":"Brezinschek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolaus","family":"Neu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hermann","family":"Dietrich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosanna Jakober","family":"And","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg","family":"Wick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,22]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"135","volume":"160","author":"Cole R. 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