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This suppression is promptly restored by the addition of indomethacin, which blocks prostaglandin synthesis, but is not markedly affected by the addition of catalase, which degrades H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>. The suppression of the IL 2 receptor expression, on the other hand, is not restored by the addition of indomethacin, nor by the simultaneous supply of both indomethacin and catalase. This discrepancy is not caused by an extreme susceptibility of the receptor expression to low prostaglandin (PG) concentrations, but rather by the presence of suppressive cells that operate through a PG\u2010independent mechanism. This suppressive mechanism accounts for the loss of the IL 2 receptors on both the Ly\u20102 and the L3T4 T cell compartment. The indomethacin\u2010treated co\u2010cultures, which manifest a normal IL 2 production but lack the IL 2 receptors, manifest an impaired DNA synthesis and contain a decreased number of T cell blasts.<\/jats:p>","DOI":"10.1002\/eji.1830190119","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T09:19:51Z","timestamp":1172740791000},"page":"119-124","source":"Crossref","is-referenced-by-count":31,"title":["Different mechanisms account for the suppression of interleukin 2 production and the suppression of interleukin 2 receptor expression in <i>Trypanosoma brucei<\/i>\u2010infected mice"],"prefix":"10.1002","volume":"19","author":[{"given":"Maarten","family":"Sileghem","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayub","family":"Darji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"Remels","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond","family":"Hamers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick De","family":"Baetselier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,22]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.11.3466"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.4049\/jimmunol.133.3.1570","volume":"13","author":"Tarleton R. 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