{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T15:39:49Z","timestamp":1759333189797},"reference-count":46,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,12,6]],"date-time":"2005-12-06T00:00:00Z","timestamp":1133827200000},"content-version":"vor","delay-in-days":6152,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1989,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In a murine model of cutaneous leishmaniasis, the importance of T cell\u2010dependent immunity has been documented by the susceptibility to parasite infection of athymic nude mice of both genetically resistant and genetically susceptible strains. T lymphocytes from uninfected mice have the capacity to promote resistance to <jats:italic>Leishmania major<\/jats:italic> infection in nude recipients, whereas T cells from mice chronically infected with <jats:italic>L. major<\/jats:italic> not only fail to mediate protection, but totally abrogate the host\u2010protective effect of normal mouse lymphocytes. Both these effects are mediated by T cells which have the phenotype L3T4Ly\u20102<jats:sup>\u2010<\/jats:sup>. To discriminate between the two activities, we have tried to separate the L3T4 population on the basis of additional cell surface markers and we have found that peripheral L3T4 lymphocytes could be subdivided according to their expression of the Ly\u201024 (Pgp\u20101) surface marker. In adoptive transfer experiments, both the Ly\u201024 and the Ly\u201024 subset of L3T4 cells from uninfected mice had the capacity to mediate resistance to infection with <jats:italic>L. major.<\/jats:italic> However, diseasepromoting activity was only found in the L3T4Ly\u201024 and not in the L3T4Ly\u201024<jats:sup>\u2010<\/jats:sup> subset of cells from mice with chronic cutaneous disease. Moreover, Ly\u201024 expression was strongly increased in lymphocytes from chronically infected mice and <jats:italic>in vitro<\/jats:italic> limiting dilution analysis confirmed that the vast majority of <jats:italic>L. major<\/jats:italic>\u2010reactive T cells was L3T4Ly\u201024. In genetically susceptible mice with chronic cutaneous leishmaniasis, Ly\u201024 therefore appears to be a marker for lymphocytes with the capacity to abrogate resistance to disease, these cells being activated and expanding in the course of progressive <jats:italic>L. major<\/jats:italic> infection. Ly\u201024 expression is a useful tool for phenotypic identification and selective enrichment of antigen\u2010activated and possibly memory T cells. It may facilitate the isolation of <jats:italic>L. major<\/jats:italic>\u2010specific T cell clones with defined activities.<\/jats:p>","DOI":"10.1002\/eji.1830190214","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T10:41:59Z","timestamp":1172745719000},"page":"307-314","source":"Crossref","is-referenced-by-count":3,"title":["L3T4 T cells promoting susceptibility to murine cutaneous leishmaniasis express the surface marker Ly\u201024 (Pgp\u20101)"],"prefix":"10.1002","volume":"19","author":[{"given":"Heidrun","family":"Moll","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Scollay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,6]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/icb.1979.2"},{"key":"e_1_2_1_3_2","first-page":"79","volume":"28","author":"Howard J. 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