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In the present report we investigated the role of the idiotypic network in the induction of experimental SLE by using a murine anti\u2010idiotypic mAb specific for the 16\/6 Id. This anti\u2010idiotypic mAb induced experimental SLE similarly to the 16\/6 Id. Thus, following immunization, in addition to 16\/6 Id<jats:sup>+<\/jats:sup> antibodies, the mice produced antibodies to various nuclear antigens: single\u2010stranded DNA, double\u2010stranded DNA, poly(I), poly(G), Ro, La, Sm and ribonucleoproteins. Similarly to the 16\/6 Id\u2010immunized mice, the mice injected with the anti\u201016\/6 Id mAb exhibited elevated erythrocyte sedimentation rate and leukopenia. The murine anti\u201016\/6 Id mAb was found to be more effective than the 16\/6 Id, in causing earlier onset of proteinuria and renal damage. These results suggest that the idiotypic network and particularly anti\u2010idiotypic antibodies specific for anti\u2010DNA common idiotypes found in SLE, play an important role in the induction of SLE in mice.<\/jats:p>","DOI":"10.1002\/eji.1830190424","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T10:48:44Z","timestamp":1172746124000},"page":"729-734","source":"Crossref","is-referenced-by-count":70,"title":["The role of anti\u2010idiotypic antibodies in the induction of experimental systemic lupus erythematosus in mice"],"prefix":"10.1002","volume":"19","author":[{"given":"Shlomo","family":"Mendlovic","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harald","family":"Fricke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yehuda","family":"Shoenfeld","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edna","family":"Mozes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,22]]},"reference":[{"key":"e_1_2_1_2_2","volume-title":"Genetics, Immunology, Virology and Clinical Aspects","author":"Talal N.","year":"1977"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.01.040183.003033"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780290601"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.7.2260"},{"key":"e_1_2_1_6_2","first-page":"205","volume":"70","author":"Shoenfeld Y.","year":"1982","journal-title":"Proc. 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