{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:28:52Z","timestamp":1790666932771,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,12,1]],"date-time":"2005-12-01T00:00:00Z","timestamp":1133395200000},"content-version":"vor","delay-in-days":6027,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1989,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The immunoglobulin (Ig) heavy (H) and light (L) chain gene rearrangements of the high incidence SJL lymphomas (reticulum cell sarcoma, RCS) have been analyzed. Both primary and transplanted RCS show rearrangements of H and \u03c7 L chains, demonstrating that these tumors are of B cell origin. These data are consistent with previous results indicating that these tumors are a mouse model for follicular lymphoma. A long\u2010term transplanted line and the <jats:italic>in vitro<\/jats:italic> line derived from it, cRCS\u2010X, have a single rearranged J<jats:sub>H<\/jats:sub>\u2212C<jats:sub>\u03b32a<\/jats:sub> fragment and one rearranged C<jats:sub>\u03b1<\/jats:sub> gene fragment which does not hybridize with a probe for the J<jats:sub>H<\/jats:sub> gene segments. These cell lines also have two rearranged J<jats:sub>\u03c7<\/jats:sub>\u2212C<jats:sub>\u03c7<\/jats:sub> fragments. Primary tumors and early passages are more heterogeneous with respect to Ig gene rearrangements, possibly because more than one B cell clone is present.<\/jats:p><jats:p>Although no synthesis of IgG<jats:sub>2a<\/jats:sub>, or of any Ig, could be detected by the <jats:italic>in vitro<\/jats:italic> cRCS\u2010X cells, these cells contain abundant poly(A)<jats:sup>+<\/jats:sup> RNA that hybridize with \u03b3<jats:sub>2a<\/jats:sub> and \u03c7 probes as well as lesser amounts of \u03b1 and \u03b5 RNA. None of these H chain RNA hybridized with probes for the J<jats:sub>H<\/jats:sub> gene segments. The \u03b5 and \u03b1 RNA are the same size as transcripts of germ\u2010line C<jats:sub>H<\/jats:sub> genes which have been identified in other systems. However, the \u03b3<jats:sub>2a<\/jats:sub> RNA are smaller than previously described germ\u2010line C<jats:sub>\u03b32a<\/jats:sub> RNA and appear to be transcribed from aberrantly rearranged J<jats:sub>H<\/jats:sub>\u2212C<jats:sub>\u03b32a<\/jats:sub> genes.<\/jats:p>","DOI":"10.1002\/eji.1830190616","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T10:47:27Z","timestamp":1172746047000},"page":"1063-1069","source":"Crossref","is-referenced-by-count":17,"title":["Reticulum cell sarcomas of SJL mice have rearranged immunoglobulin heavy and light chain genes"],"prefix":"10.1002","volume":"19","author":[{"given":"Janet","family":"Stavnezer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L.","family":"Lasky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas M.","family":"Ponzio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margrit P.","family":"Scheid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Jeanette Thorbecke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.3109\/08830188609056610"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"679","DOI":"10.4049\/jimmunol.140.2.679","volume":"140","author":"Lasky J. 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