{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T09:57:57Z","timestamp":1789984677183,"version":"4.0.1"},"reference-count":18,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2005,12,6]],"date-time":"2005-12-06T00:00:00Z","timestamp":1133827200000},"content-version":"vor","delay-in-days":6002,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1989,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Immunohistochemistry has been used to investigate disulfide\u2010 and non\u2010disulfide\u2010linked forms of the T cell receptor \u03b3\/\u03b4 heterodimer (TcR \u03b3\/\u03b4) in blood and intestinal epithelium of normal human small intestine, intestine of patients with untreated coeliac disease (in whom T cells expressing TcR \u03b3\/\u03b4 are disproportionately raised), intestine of patients with tropical malabsorption, and in the human fetus. In blood from adult volunteers, 90% of T cells expressing TcR \u03b3\/\u03b4 use the disulfide\u2010linked form. In contrast in the epithelium in normal small intestine, coeliac disease and tropical malabsorption, most of the T cells expressing TcR \u03b3\/\u03b4 use the non\u2010disulfide\u2010linked form. This is especially prominent in untreated coeliac disease where the increase in TcR \u03b3\/\u03b4 T cells is mainly restricted to those using the non\u2010disulfide\u2010linked form. In human fetal small intestinal epithelium, however, only cells using the disulfide\u2010linked form are present. These variations in expression of different forms of TcR \u03b3\/\u03b4 in the gut epithelium in different conditions suggests that antigen, or some as yet undefined factor may determine the frequency of each subpopulation.<\/jats:p>","DOI":"10.1002\/eji.1830190728","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T10:46:58Z","timestamp":1172746018000},"page":"1335-1338","source":"Crossref","is-referenced-by-count":191,"title":["Expression of disulfide\u2010linked and non\u2010disulfide\u2010linked forms of the T cell receptor \u03b3\/\u03b4 heterodimer in human intestinal intraepithelial lymphocytes"],"prefix":"10.1002","volume":"19","author":[{"given":"Jo","family":"Spencer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter G.","family":"Isaacson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim C.","family":"Diss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas T.","family":"Macdonald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,6]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.4049\/jimmunol.138.5.1502","volume":"138","author":"Brenner M. 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