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In contrast, it is absent from T, B and erythroblastoid cells. The antigen HC1\/6 is also expressed by normal tissue macrophages in tonsil, lung and kidney, as well as in skin biopsies from pathologies such as sarcoidosis and lepromatous leprosy. The expression of the HC1\/6 antigen is increased up to 5\u2010fold when U\u2010937 (promonocytic) and HL\u201060 (myelomonocytic) cell lines are stimulated with phorbol 12\u2010myristate 13\u2010acetate. Conversely, the expression of the HC1\/6 antigen is down\u2010regulated in monocytes upon treatment with interferon\u2010\u03b3. 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