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BN rats treated with sodium aurothiopropanol sulfonate or D\u2010penicillamine, as well as (LEW\u00d7BN)F<jats:sub>1<\/jats:sub> hybrids transferred with BN rat spleen cells, developed quite similar autoimmune abnormalities. In the present study, it is shown that immunoglobulins bearing such \u201cpublic\u201d idiotypes are also produced and deposited in the kidney in these three models. The CRId here described may, therefore, be considered as a marker of sets of recurrently expressed V region genes during the course of these autoimmune disorders. Anti\u2010self class II T cells are present in the three models of toxin\u2010induced autoimmunity and anti\u2010allo class II T cells are responsible for the chronic graft\u2010<jats:italic>vs.<\/jats:italic>\u2010host reaction. The same B cell clones are probably triggered during these processes as a consequence of a polyclonal B cell activation mediated by anti\u2010class II T cells.<\/jats:p>","DOI":"10.1002\/eji.1830200115","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T11:06:55Z","timestamp":1172747215000},"page":"101-105","source":"Crossref","is-referenced-by-count":19,"title":["Rat anti\u2010glomerular basement membrane antibodies in toxin\u2010induced autoimmunity and in chronic graft\u2010<i>vs.<\/i>\u2010host reaction share recurrent idiotypes"],"prefix":"10.1002","volume":"20","author":[{"given":"Jean\u2010Charles","family":"Gu\u00e9ry","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herv\u00e9","family":"Tournade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucette","family":"Pelletier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elvira","family":"Druet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Druet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,17]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830120716"},{"key":"e_1_2_1_3_2","first-page":"211","volume":"1","author":"Pelletier L.","year":"1987","journal-title":"Nephrol. 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