{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T15:57:19Z","timestamp":1772899039150,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,11,17]],"date-time":"2005-11-17T00:00:00Z","timestamp":1132185600000},"content-version":"vor","delay-in-days":5799,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1990,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cultured mast cells derived from murine bone marrow were investigated for the presence of specific interferon\u2010\u03b3 (IFN\u2010\u03b3) receptors, and for the effects of IFN\u2010\u03b3 on mast cell proliferation. <jats:sup>125<\/jats:sup>I\u2010labeled recombinant IFN\u2010\u03b3 (<jats:sup>125<\/jats:sup>I\u2010Mu\u2010rIFN\u2010\u03b3) was shown to bind to high\u2010affinity receptors on these cells. Scatchard analysis of binding data indicated the presence of about 500 homogeneous binding sites per cell, with an apparent equilibrium dissociation constant of 3\u00d710<jats:sup>\u221210<\/jats:sup> M. The binding of <jats:sup>125<\/jats:sup>I\u2010Mu\u2010rIFN\u2010\u03b3 to mast cells was inhibited by unlabeled Mu\u2010rIFN\u2010\u03b3 but not by unlabeled Mu\u2010IFN\u2010\u03b1\/\u03b2. Cross\u2010linking of <jats:sup>125<\/jats:sup>I\u2010Mu\u2010rIFN\u2010\u03b3 to mast cell membrane proteins using a cross\u2010linking agent yielded a predominant complex of 100 \u00b1 10 kDa on sodium dodecyl sulfate\u2010polyacrylamide gel electrophoresis and autoradiography which IFN\u2010\u03b3\u2010receptor complex. To assess the biological significance of these receptors, we studied the effects of Mu\u2010rIFN\u2010\u03b3 on mast cell proliferation, which was markedly inhibited in mast cell precursors but not in mature mast cells. These <jats:italic>in vitro<\/jats:italic> results are in agreement with the antiproliferative effect of IFN\u2010\u03b3 previously reported for other hematopoietic progenitors, and suggest that IFN\u2010\u03b3 could find its application in the treatment of human systemic mastocytosis.<\/jats:p>","DOI":"10.1002\/eji.1830200117","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T11:06:55Z","timestamp":1172747215000},"page":"113-117","source":"Crossref","is-referenced-by-count":25,"title":["Specific high\u2010affinity receptors for interferon\u2010\u03b3 on mouse bone marrow\u2010derived mast cells: inhibitory effect of interferon\u2010\u03b3 on mast cell precursors"],"prefix":"10.1002","volume":"20","author":[{"given":"Jo\u00eblle","family":"Nafziger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Arock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Jacques","family":"Guillosson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juana","family":"Wietzerbin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,17]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00201966"},{"key":"e_1_2_1_3_2","volume-title":"Interferons and other regulatory cytokines","author":"De Maeyer E.","year":"1988"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.19.5842"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"240","DOI":"10.4049\/jimmunol.132.1.240","volume":"132","author":"Kelley V. 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