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Increased ICAM\u20101 appeared within 24 h of thyroid cell stimulation with cytokines and was not inhibited by the antithyroid drug methimazole. Autologous and allogeneic lymphocyte\u2010thyroid cell cluster formation, assessed by flow cytometry, was reduced by about one\u2010third in the presence of a monoclonal antibody against ICAM\u20101, regardless of whether thyroid cells were expressing basal levels of ICAM\u20101 or had been stimulated with interferon\u2010\u03b3. The cytotoxicity produced by interleukin 2\u2010stimulated allogeneic lymphocytes was not consistently inhibited by anti\u2010ICAM\u20101 antibody, but phytohemagglutinin\u2010stimulated lymphocytes showed a reduction of 23% \u2013 28% in cytotoxicity against untreated or interferon\u2010\u03b3 stimulated thyroid cells when the anti\u2010ICAM\u20101 monoclonal antibody was present. Finally, thyroid cells could be infected by rhinovirus, confirming the presence of fully functional ligand. These results show that ICAM\u20101 expression by thyroid cells may enhance immune cell recognition and play some role in cytotoxicity, features which could be important in the initiation or perpetuation of autoimmune thyroiditis.<\/jats:p>","DOI":"10.1002\/eji.1830200207","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T11:48:34Z","timestamp":1172749714000},"page":"271-275","source":"Crossref","is-referenced-by-count":46,"title":["Functional analysis of intercellular adhesion molecule\u20101\u2010expressing human thyroid cells"],"prefix":"10.1002","volume":"20","author":[{"given":"Anthony P.","family":"Weetman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Freeman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leszeck K.","family":"Borysiewicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. William","family":"Makgoba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,17]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1210\/edrv-5-2-309"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1210\/edrv-6-2-183"},{"key":"e_1_2_1_4_2","first-page":"115","author":"Bottazzo G. F.","year":"1983","journal-title":"Lancet"},{"key":"e_1_2_1_5_2","first-page":"21","volume":"5","author":"Weetman A. 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